328546-84-5Relevant academic research and scientific papers
Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1- hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase
Tikhe, Jayashree G.,Webber, Stephen E.,Hostomsky, Zdenek,Maegley, Karen A.,Ekkers, Anne,Li, Jianke,Yu, Xiao-Hong,Almassy, Robert J.,Kumpf, Robert A.,Boritzki, Theodore J.,Zhang, Cathy,Calabrese, Chris R.,Curtin, Nicola J.,Kyle, Suzanne,Thomas, Huw D.,Wang, Lan-Zhen,Calvert, A. Hilary,Golding, Bernard T.,Griffin, Roger J.,Newell, David R.
, p. 5467 - 5481 (2007/10/03)
The design, synthesis, and biological evaluation of potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) are reported. A novel series of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones were designed using a combination of protein structure-base
Tricyclic inhibitors of poly(ADP-ribose) polymerases
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, (2008/06/13)
Compounds of the formula shown below are poly(ADP-ribosyl)transferase inhibitors: Such compounds are useful as therapeutics in treating cancers and in ameliorating the effects of stroke, head trauma, and neurodegenerative disease.
