328557-42-2

Upstream product

• 7693-46-1 4-Nitrophenyl chloroformate 
• 328557-41-1 (4R,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-oxazolidin-2-one 
• 328387-94-6 (S)-1-Amino-1-(3,4-difluoro-phenyl)-propan-2-ol 
• 328387-92-4 (2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-(3,4-difluorophenyl)-1-propanone 
• 328387-93-5 (2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-(3,4-difluorophenyl)-1-propanone oxime 

Downstream Products

• 218450-16-9 (4R,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine-3-carboxylic acid {3-[4-(4-fluoro-phenyl)-piperidin-1-yl]-propyl}-amide 

Relevant academic research and scientific papers

SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS

This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therepeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier.

Determination of the relative and absolute stereochemistry of a potent and α(1A)-selective adrenoceptor antagonist

The binding affinities and selectivities of antagonists 1-4 for the α(1A)-adrenoceptor are dependent on the stereochemical orientation of the groups at the C-4 and C-5 positions of the oxazolidinone ring. The unambiguous assignment of the relative and abs