32870-21-6

Basic information

• Product Name: 2(1H)-Quinolinone, 1-ethyl-4-phenyl-
• CAS NO: 32870-21-6
• Molecular Formula: C17H15NO
• Molecular Weight: 249.312
• Mol File: 32870-21-6.mol

Chemical Properties

• CAS DataBase Reference: 2(1H)-Quinolinone, 1-ethyl-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinolinone, 1-ethyl-4-phenyl-(32870-21-6)
• EPA Substance Registry System: 2(1H)-Quinolinone, 1-ethyl-4-phenyl-(32870-21-6)

Safety Data

• Hazardous Substances Data: 32870-21-6(Hazardous Substances Data)

Upstream product

• 40624-85-9 3-oxo-3-phenyl-propionic acid-(N-ethyl-anilide) 
• 1039-51-6 2,4-diphenylquinoline 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 85-99-4 2-acetamidobenzophenone 
• 690661-18-8 N-ethyl-N-(o-benzoylphenyl)acetamide 
• 75-03-6 ethyl iodide 

Relevant articles and documents

A novel and facile synthesis of 4-arylquinolin-2(1H)-ones under metal-free conditions

Abstract A novel and facile synthesis of 4-arylquinolin-2(1H)-ones without metal catalysis has been developed. This reaction involved cyclization/elimination steps and was performed under metal-free conditions using inexpensive reagents such as NaI, selec

Facile synthesis of 4-phenylquinolin-2(1H)-one derivatives from N-acyl-o-aminobenzophenones

An efficient synthesis of 4-phenylquinolin-2(1H)-one derivatives has been achieved in a one-pot reaction from N-acyl-o-aminobenzophenones 1a-c (a: acyl=acetyl; b: acyl=propanoyl; c: acyl=heptanoyl) using NaH as a base. Treatment of 1 with NaH provided the quinolones 2a-c with 62-83% yields, whereas the reaction in the presence of alkyl iodide (alkyl=methyl, ethyl, n-octyl) gave the corresponding N-alkylated quinolones 3a-g in 75-95% yields. The alkylation reaction of 4-phenylquinolin-2(1H)-one 2a with alkyl halide gave a mixture of N-alkylated and O-alkylated products. Comparison of IR and NMR data of the N-alkylated and O-alkylated compounds with those of 2a-c indicated that 2a-c exist as the lactam form.

OXIDATIVE ELIMINATION OF PHENYL GROUP FROM α POSITION OF QUATERNARY QUINOLINIUM SALTS

Action of alkaline solution of potassium ferricyanide on the quaternary quinolinium salts IIIa to IIIc results in splitting off of 2-phenyl substituent and formation of the quinolones IVa-IVc.A possible mechanism of this transformation is discussed.