32884-52-9

Basic information

• Product Name: Ethanone, 1-[4-[[(4-chlorophenyl)methylene]amino]phenyl]-
• CAS NO: 32884-52-9
• Molecular Formula: C15H12ClNO
• Molecular Weight: 257.719
• Mol File: 32884-52-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[4-[[(4-chlorophenyl)methylene]amino]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[4-[[(4-chlorophenyl)methylene]amino]phenyl]-(32884-52-9)
• EPA Substance Registry System: Ethanone, 1-[4-[[(4-chlorophenyl)methylene]amino]phenyl]-(32884-52-9)

Safety Data

• Hazardous Substances Data: 32884-52-9(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 99-92-3 p-aminobenzophenone 

Downstream Products

• 38283-38-4 4-(2-chloroacetamido)acetophenone 
• 381666-51-9 3-(4-Acetylphenyl)-2-(4-chlorophenyl)-2,3-dihydro-5,6-diphenyl-4H-1,3-oxazin-4-one 
• 52927-44-3 dimethyl 2-(4-chlorobenzylidene)malonate 
• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 133093-27-3 1-(4-acetylphenyl)-3-chloro-4-(4-chlorophenyl)azetidin-2-one 
• 1467080-32-5 C₂₅H₂₁Cl₂N₃O₃ 
• 1467080-30-3 C₂₆H₂₄Cl₂N₄O 
• 1467080-29-0 C₂₄H₁₉Cl₂N₃O₂ 
• 1467080-28-9 C₂₈H₂₈Cl₂N₄O 
• 1467080-27-8 C₂₄H₁₈Cl₃N₃O 
• 1467080-26-7 C₂₄H₁₈Cl₂N₄O₃ 
• 1467080-25-6 C₂₆H₂₃Cl₂N₃O₃ 
• 1467080-24-5 C₂₄H₁₉Cl₂N₃O₂ 
• 1467080-23-4 C₂₄H₁₈Cl₃N₃O 

Relevant articles and documents

Synthesis, Antiproliferative and Cytotoxic Activities, DNA Binding Features and Molecular Docking Study of Novel Enamine Derivatives

Novel enamine derivatives were synthesized from the reaction of lactone and chalcones and their antiproliferative and cytotoxic activities against six cancer cell lines (e. g., HeLa, HT29, A549, MCF7, PC3 and Hep3B) and one normal cell lines (e. g., FL) were investigated along with their mode of interactions with CT-DNA. Most of the enamine derivatives with IC50 values of 86–168 μM demonstrated much stronger antiproliferative activity than the starting molecules against the cancer cells. While, among the enamine derivatives, four compounds displayed higher cytotoxic potency than the control drugs (5-fluorouracil and cisplatin) against the Hep3B cell lines, these compounds did not exhibit any significant toxicity against normal cells, FL. The UV/VIS spectral data suggest that eight compounds cause hypochromism with a slight bathochromic shift (～6 nm), indicating that they bind to the DNA by way of an intercalative or minor groove binding mode. The binding constants of the compounds are in the range of 0.1×103 M?1–2.3×104 M?1. The antiproliferative activity of studied enamine derivatives could possibly be due to their DNA binding as well as their cytotoxic properties. In addition to these assays, the chalcones and enamine derivatives were investigated by molecular docking to calculate the synergistic effect of antiproliferative activities against six human cancer cell lines.

Design, synthesis and in vitro antimalarial evaluation of new quinolinylhydrazone derivatives

A series of novel quinolinylhydrazones (5a-f) was synthesized by the condensation reaction of 2,6-diaryl-substituted piperidin-4-ones (4a-f) with 7-chloro-4-hydrazinoquinoline (2). Novel quinolinylhydrazones containing Shiff bases 8a-f and 11a-f were obta

Chemoselectivity in reactions of an α-diazo-β-diketone with some conjugative double-bond systems

Reactions of 2-diazo-1,3-diphenylpropane-1,3-dione with α,β-unsaturated aldehydes and ketones, and keto-imines, in refluxing anhydrous toluene indicate that benzoyl(phenyl)ketene, which is generated by the thermal Wolff rearrangement of 2-diazo-1,3-diphen