32886-70-7

Upstream product

• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 102240-27-7 N-(3',4'-dimethoxyphenethyl)-3,4,5-trimethoxybenzamide 
• 3161-21-5 1-(3,4,5-trimethoxylphenyl)-3,4-dihydro-6,7-dimethoxyisoquinoline 

Relevant academic research and scientific papers

Josiphos-Type Binaphane Ligands for Iridium-Catalyzed Enantioselective Hydrogenation of 1-Aryl-Substituted Dihydroisoquinolines

Convenient synthesis and useful application of a series of Josiphos-type binaphane ligands were described. The iridium complexes of these chiral diphosphines displayed excellent enantioselectivity and good reactivity in the asymmetric hydrogenation of challenging 1-aryl-substituted dihydroisoquinoline substrates (full conversions, up to >99% ee, 4000 TON). The use of 40% HBr (aqueous solution) as an additive dramatically improved the asymmetric induction of these catalysts. This transformation provided a highly efficient and enantioselective access to chiral 1-aryl-substituted tetrahydroisoquinolines, which were of great importance and common in natural products and biologically active molecules.