32886-98-9Relevant academic research and scientific papers
Penicillin esters, salts thereof and methods for their preparation
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, (2008/06/13)
The invention relates to a new series of penicillin esters and salts thereof, to methods of their preparation and to intermediates in the production of the esters of the general formula STR1 in which R1 and R2 represent an alkyl radical having from 1 to 6 carbon atoms, a cycloalkyl or cycloalkylalkyl radical the cycloalkyl part having from 3 to 10 carbon atoms, or R1 and R2 together with the nitrogen atom represent a heterocyclic ring with from 4 to 8 carbon atoms; R3 represents radicals known from natural, biosynthetic, and semisynthetic penicillins; and pharmaceutically acceptable salts thereof. The new compounds are efficiently absorbed from the gastrointestinal tract and after the absorption they are rapidly transformed into the corresponding free penicillins and amidinopenicillanic acids, whereby a broad-spectrum infection can be combated.
6-Aminopenicillanic acid derivatives
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, (2008/06/13)
The invention relates to hitherto unknown derivatives of 6-aminopenicillanic acids of the formula SPC1 In which R1 and R2 are similar or different aliphatic, cycloaliphatic, aromatic or heterocyclic substituents linked directly or through alkyl groups to the nitrogen atom, or R1 and R2 together with the nitrogen atom form a heterocyclic ring, and R3 is a hydroxyl or substituted hydroxyl group; to pharmaceutically acceptable salts, and to methods for producing these new compounds having a strong antibacterial effect, especially on gram-negative bacteria, to pharmaceutical preparations in dosage unit forms containing the compounds of the invention solely, or in synergistic mixtures with penicillins, and to methods of treating patients with the dosage units.
