328931-56-2

Basic information

• Product Name: BenzaMide, 4-broMo-N-(2-phenylethyl)-
• Synonyms: BenzaMide, 4-broMo-N-(2-phenylethyl)-
• CAS NO: 328931-56-2
• Molecular Formula: C₁₅H₁₄BrNO
• Molecular Weight: 304.18176
• Mol File: 328931-56-2.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BenzaMide, 4-broMo-N-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzaMide, 4-broMo-N-(2-phenylethyl)-(328931-56-2)
• EPA Substance Registry System: BenzaMide, 4-broMo-N-(2-phenylethyl)-(328931-56-2)

Safety Data

• Hazardous Substances Data: 328931-56-2(Hazardous Substances Data)

Upstream product

• 586-75-4 4-chlorobenzoyl chloride 
• 1590361-11-7 O-diethylcarbamoyl-N-phenethylhydroxylamine 
• 75748-11-7 (4-bromophenyl)(trimethylsilyl)methanone 
• 1590361-20-8 N-tert-butoxycarbonyl-O-diethylcarbamoyl-N-phenethylhydroxylamine 
• 103-63-9 1-phenyl-2-bromoethane 
• 873-75-6 4-bromobenzenemethanol 
• 64-04-0 phenethylamine 
• 1122-91-4 4-bromo-benzaldehyde 
• 586-76-5 4-Bromobenzoic acid 

Downstream Products

• 742085-03-6 N-[2-(4-acetylphenyl)ethyl]-4-bromobenzamide 
• 1239713-17-7 2-(4-bromophenyl)-5-phenyl-4,5-dihydro-1,3-oxazole 
• 14492-02-5 2-(4-bromophenyl)-5-phenyloxazole 

Relevant articles and documents

Chemoselective Amide-Forming Ligation Between Acylsilanes and Hydroxylamines Under Aqueous Conditions

We report the facile amide-forming ligation of acylsilanes with hydroxylamines (ASHA ligation) under aqueous conditions. The ligation is fast, chemoselective, mild, high-yielding and displays excellent functional-group tolerance. Late-stage modifications of an array of marketed drugs, peptides, natural products, and biologically active compounds showcase the robustness and functional-group tolerance of the reaction. The key to the success of the reaction could be the possible formation of the strong Si?O bond via a Brook-type rearrangement. Given its simplicity and efficiency, this ligation has the potential to unfold new applications in the areas of medicinal chemistry and chemical biology.

Asymmetric Transfer Hydrogenation of Unhindered and Non-Electron-Rich 1-Aryl Dihydroisoquinolines with High Enantioselectivity

The use of arene/Ru/TsDPEN catalysts bearing a heterocyclic group on the TsDPEN in the asymmetric transfer hydrogenation (ATH) of dihydroisoquinolines (DHIQs) containing meta- or para-substituted aromatic groups at the 1-position results in the formation of products of high enantiomeric excess. Previously, only 1-(ortho-substituted)aryl DHIQs, or with an electron-rich fused ring gave products with high enantioselectivity; therefore, this approach solves a long-standing challenge for imine ATH.

Direct oxidative amidation of aldehydes with amines catalyzed by heteropolyanion-based ionic liquids under solvent-free conditions via a dual-catalysis process

A simple and efficient procedure for the synthesis of amides directly from aldehydes and amines catalyzed by heteropolyanion-based ionic liquids under solvent-free conditions has been reported. The practical protocol was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, solvent-free media, and operational simplicity are the main highlights. The proposed dual-catalysis mechanistic pathway was briefly investigated. Furthermore, the heteropolyanion-based ionic liquids were easily reusable for this oxidative amidation.