14492-02-5

Basic information

• Product Name: Oxazole, 2-(4-bromophenyl)-5-phenyl-
• Synonyms: 5-Phenyl-2-p-bromo-phenyl-oxazol
• CAS NO: 14492-02-5
• Molecular Formula: C15H10BrNO
• Molecular Weight: 300.154
• Mol File: 14492-02-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Oxazole, 2-(4-bromophenyl)-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 2-(4-bromophenyl)-5-phenyl-(14492-02-5)
• EPA Substance Registry System: Oxazole, 2-(4-bromophenyl)-5-phenyl-(14492-02-5)

Safety Data

• Hazardous Substances Data: 14492-02-5(Hazardous Substances Data)

Upstream product

• 5468-37-1 2-aminoacetophenone hydrochloride 
• 1122-91-4 4-bromo-benzaldehyde 
• 3959-07-7 4-Bromobenzylamine 
• 70-11-1 α-bromoacetophenone 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 100-42-5 styrene 
• 107047-10-9 p-bromobenzylazide 
• 328931-56-2 4-bromo-N-(2-phenylethyl)benzamide 
• 586-75-4 4-chlorobenzoyl chloride 
• 6607-46-1 (1,2-dibromovinyl)benzene 
• 698-67-9 p-bromobenzamide 
• 37611-23-7 4-Bromo-N-[1-(2-oxo-2-phenylethyl)]benzamide 
• 63-91-2 L-phenylalanine 
• 532-27-4 1-chloroacetophenone 

Relevant articles and documents

Divergent Conversion of N-Acyl-isoxazol-5(2 H)-ones to Oxazoles and 1,3-Oxazin-6-ones Using Photoredox Catalysis

The fragmentation of N-acyl-isoxazol-5-ones using visible light photoredox catalysis has been disclosed. The catalyst-controlled divergent mechanisms, namely the oxidative and reductive quenching catalytic cycle, are utilized. Various oxazoles and 1,3-oxazin-6-ones are selectively obtained from the same isoxazol-5-one skeleton under mild conditions.

A facile synthesis of 2,5-disubstituted oxazoles via a copper-catalyzed cascade reaction of alkenes with azides

A novel and efficient approach to the synthesis of 2,5-disubstituted oxazoles is developed via a 1,3-dipolar cycloaddition/ring cleavage/1,2-H migration/denitrogenation/copper-catalyzed aerobic oxidative dehydrogenative cyclization cascade. The desired products can be obtained from readily available aromatic terminal alkenes and azides employing air as the oxidant under mild conditions, and it offers an attractive alternative method for the synthesis of oxazole derivatives.

One-pot conversion of amino acids into 2,5-disubstituted oxazoles: No metals needed

2,5-Disubstituted oxazoles with a variety of alkyl and aryl groups are efficiently formed from N-acylamino acids, by a one-pot radical decarboxylation- oxidation-enolization and iodine-promoted cyclization process. Remarkably, the reaction takes place under mild conditions, and no metal catalysis is needed. The process can be useful for the direct modification of small peptides.