329008-88-0Relevant academic research and scientific papers
Macrocyclic Compounds Useful as Bace Inhibitors
-
Page/Page column 51-52, (2008/12/05)
The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers
Lawrence, Nicholas J.,Rennison, David,Woo, Meiki,McGown, Alan T.,Hadfield, John A.
, p. 51 - 54 (2007/10/03)
A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest. (C) 2000 Elsevier Science Ltd.
