329009-20-3Relevant academic research and scientific papers
Process for the preparation of racemic sertraline
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, (2008/06/13)
The invention relates to a process for preparing cis-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, or racemic sertraline, corresponding to formula (I) in salt form, starting with 4-(3,4-dichlorophenyl)tetralone of formula (II) according to which (a) the 4-(3,4-dichlorophenyl)tetralone of formula (II) is reacted with N-methylformamide in the presence of formic acid, (b) the reaction medium obtained according to (a) is treated with a base, and (c) the racemic sertraline salt is separated out by selective crystallization with an acid. The invention also relates to N-methylformamide-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine and to its use to obtain racemic sertraline.
Process for preparing sertraline
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, (2008/06/13)
The invention provides the substantially geometrically pure cis-stereoisomeric form of a compound of formula (I) and the substantially geometrically and optically pure cis-stereoisomeric form of a compound of formula (II): STR1 wherein R1 is H
Process for preparing sertraline intermediates
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, (2008/06/13)
The invention provides the substantially geometrically and optically pure trans-stereoisomeric form of a compound of formula (I): STR1 wherein R1 is H or C1 -C4 alkyl, together with processes for its preparation. The compo
