329022-38-0Relevant academic research and scientific papers
Synthesis and structure activity relationships of 5-substituted-4′-thio-β-D-arabinofuranosylcytosines
Tiwari,Shortnacy-Fowler,Cappellacci,Waud,Parker,Montgomery,Secrist III
, p. 2005 - 2017 (2007/10/03)
Four 5-substituted (chloro, fluoro, bromo, methyl) 1-(4-thio-β-D-arabinofuranosyl) cytosines and their α anomers were synthesized by a facile route in high yields. All of these nucleosides were evaluated for cytotoxicity against a panel of human tumor cell lines in vitro. Only 5-fluoro-1-(4-thio-β-D-arabinofuranosyl)cytosine was found to be highly cytotoxic in all the cell lines and was further evaluated in vivo.
