3291-07-4Relevant academic research and scientific papers
A Novel Beckmann Fission Reaction of 2-Aminocyclohexanone Oxime
Sato, Haruyo,Imamura, Shinzo,Kitano, Yukishige
, p. 895 - 896 (1984)
2-(4-Cyanobutyl)-4,5,6,7-tetrahydrobenzimiazole was obtained by treating 2-aminocyclohexanone oxime with ethyl acetimidate hydrochloride in acetic acid at below 50 deg C, though only 2-methyl-4,5,6,7-tetrahydrobenzimidazole was produced by the reaction of 2-aminocyclohexanone oxime and free ethyl acetimidate in neutral solvents.A novel Beckmann fission reaction of dimeric 2-aminocyclohexanone oxime is presumed to participate in the formation of 2-(4-cyanobutyl)-4,5,6,7-tetrahydrobenzimidazole.
SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS
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Page/Page column 203, (2015/06/08)
Amine substituted pyridine and pyrazine compounds and forms thereof that inhibit the function and reduce the level of B -cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
