329204-47-9Relevant academic research and scientific papers
Synthesis and evaluation of novel α-fluorinated (E)-3-((6- methylpyridin-2-yl)ethynyl)cyclohex-2-enone-O-methyl oxime (ABP688) derivatives as metabotropic glutamate receptor subtype 5 PET radiotracers
Sephton, Selena Milicevic,Mu, Linjing,Schibli, Roger,Kraemer, Stefanie D.,Ametamey, Simon M.,Schweizer, W. Bernd
supporting information, p. 7154 - 7162,9 (2020/09/09)
In the search for an optimal fluorine-18-labeled positron emission tomography (PET) radiotracer for imaging metabotropic glutamate receptor subtype 5 (mGluR5), we have prepared a series of five α-fluorinated derivatives based on the ABP688 structural mani
Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists
Chua, Peter C.,Nagasawa, Johnny Y.,Bleicher, Leo S.,Munoz, Benito,Schweiger, Edwin J.,Tehrani, Lida,Anderson, Jeffrey J.,Cramer, Merryl,Chung, Janice,Green, Mitchell D.,King, Chris D.,Reyes-Manalo, Grace,Cosford, Nicholas D.P.
, p. 4589 - 4593 (2007/10/03)
Structure-activity relationship studies leading to the discovery of novel mGlu5 receptor antagonists are described. These compounds show high in vitro potency, have good in vivo receptor occupancy, and a reasonable intravenous pharmacokinetic profile.
