329204-72-0Relevant academic research and scientific papers
Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists
Chua, Peter C.,Nagasawa, Johnny Y.,Bleicher, Leo S.,Munoz, Benito,Schweiger, Edwin J.,Tehrani, Lida,Anderson, Jeffrey J.,Cramer, Merryl,Chung, Janice,Green, Mitchell D.,King, Chris D.,Reyes-Manalo, Grace,Cosford, Nicholas D.P.
, p. 4589 - 4593 (2005)
Structure-activity relationship studies leading to the discovery of novel mGlu5 receptor antagonists are described. These compounds show high in vitro potency, have good in vivo receptor occupancy, and a reasonable intravenous pharmacokinetic profile.
