329218-12-4

Basic information

• Product Name: (3-BROMO-4-CHLORO-PHENYL)-METHANOL
• Synonyms: (3-BROMO-4-CHLORO-PHENYL)-METHANOL;3-Bromo-4-chlorobenzyl alcohol;3-Bromo-4-chlorobenzenemethanol;(3-Bromo-4-chlorophenyl)
• CAS NO: 329218-12-4
• Molecular Formula: C₇H₆BrClO
• Molecular Weight: 221.48
• Mol File: 329218-12-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 307.0±27.0 °C(Predicted)
• Appearance: /
• Density: 1.685
• Storage Temp.: Room temperature.
• PKA: 13.89±0.10(Predicted)
• CAS DataBase Reference: (3-BROMO-4-CHLORO-PHENYL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (3-BROMO-4-CHLORO-PHENYL)-METHANOL(329218-12-4)
• EPA Substance Registry System: (3-BROMO-4-CHLORO-PHENYL)-METHANOL(329218-12-4)

Safety Data

• Hazardous Substances Data: 329218-12-4(Hazardous Substances Data)

Usage

General Description

(3-Bromo-4-chloro-phenyl)-methanol is a chemical compound with the molecular formula C7H6BrClO. It is a white to light yellow crystalline powder and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. (3-BROMO-4-CHLORO-PHENYL)-METHANOL is also used as a building block in the development of organic compounds and has potential applications in the field of medicinal chemistry. It is important to handle (3-Bromo-4-chloro-phenyl)-methanol with caution as it may cause irritation to the skin, eyes, and respiratory system upon contact or inhalation, and safety measures should be in place when working with this chemical.

Upstream product

• 76008-75-8 3-bromo-4-chlorobenzoic acid ethyl ester 
• 42860-10-6 3-bromo-4-chlorobenzoic acid 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 107947-17-1 methyl 3-bromo-4-chlorobenzoate 

Downstream Products

• 1380604-87-4 tert-butyl 1-(3-amino-4-chlorobenzyl)cyclopropanecarboxylate 
• 1380604-85-2 tert-butyl 1-(3-bromo-4-chlorobenzyl)cyclopropanecarboxylate 
• 1380604-86-3 tert-butyl 1-[3-(benzylamino)-4-chlorobenzyl]cyclopropanecarboxylate 
• 1380606-11-0 tert-butyl 1-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}benzyl)cyclopropanecarboxylate 
• 1380606-41-6 tert-Butyl 1-(3-amino-4-cyclopropylbenzyl)cyclopropanecarboxylate 
• 1380604-16-9 (+)-1-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}benzyl)cyclopropanecarboxylic acid 
• 1079402-22-4 2-(2-chloro-5-methoxymethylphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 1622068-77-2 3-[3-(2-chloro-5-hydroxymethyl-phenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-benzoic acid methyl ester 
• 1609540-88-6 tert-butyl((4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)dimethylsilane 
• 1609540-77-3 5-(((tert-butyldimethylsilyl)oxy)methyl)-2-chlorobenzoic acid 
• 1609540-81-9 ((3-bromo-4-chlorobenzyl)oxy)(tert-butyl)dimethylsilane 
• 1313042-58-8 2-(3-bromo-4-chloro-benzyl)-isoindole-1,3-dione 

Relevant articles and documents

N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE

The present application relates to novel substituted 2-(piperidin-1-yl)acetamide derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.

N3-SUBSTITUTED IMINOPYRIMIDINONES AS RENIN INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides provides certain N3-substituted iminopyrimidinones of Formula (I): and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoiso

INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS

The present invention discloses and claims a series of substituted indolyl-piperidinyl benzylamines of formula (I), wherein R1, R2 and R3 are as described herein. More specifically, the compounds of this invention are inhibitors of β-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted indolyl-piperidinyl benzylamines. In one of the embodiments, there is provided the compounds of formula (I) wherein R3 is (II).