76008-75-8Relevant academic research and scientific papers
A convergent strategy towards febrifugine and related compounds
Maiden,Mbelesi,Procopiou,Swanson,Harrity
, p. 4159 - 4169 (2018/06/12)
We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate the application of a recent Rh-catalyzed quinazolinone synthesis for the facile generation of febrifugine analogs.
Regioselective synthesis of benzimidazolones via cascade C-N coupling of monosubstituted ureas
Ernst, Johannes B.,Tay, Nicholas E. S.,Jui, Nathan T.,Buchwald, Stephen L.
supporting information, p. 3844 - 3846 (2014/08/05)
A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote a cascade of two discrete chemoselective C-N bond-forming processes that allows the highly selective and predictable formation of complex heterocycles from simple, readily available starting materials.
INDAZOLE DERIVATIVES THAT INHIBIT TRPV1 AND USES THEREOF
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Page/Page column 34, (2008/06/13)
Compounds of formula (I) wherein R3, R7, R9 and L are defined in the description are TRPV1 antagonists that exhibit low inhibitory activity against CYP3A4. Compositions comprising such compounds and methods for treating co
Oxime derivatives for the treatment of dyslipidemia and hypercholesteremia
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, (2008/06/13)
The present invention relates to compounds of Formula (I) which may be useful in the treatment of diseases, such as, metabolic disorders, dyslipidemia and/or hyperchloesterolemia: 1
Heterocyclic derivatives for the treatment of diabetes and other diseases
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, (2008/06/13)
The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.
Use of Potassium Bromate: Bromination of Halobenzenes and Halobenzoic Acids
Banerjee, Amalendu,Banerjee, Gopal Chandra,Dutt, Sachchidananda,Banerjee, Santa (Mrs.),Samaddar, Haraprasad
, p. 640 - 642 (2007/10/02)
Syntheses of bromo compounds by the bromination of halobenzenes and halobenzoic acids using potassium bromate under acidic condition have been discussed.
