32933-40-7

Usage

Uses

Used in Chemical Synthesis:
2-Cyano-N-(4-sulfamoyl-phenyl)-acetamide is used as a chemical intermediate for the synthesis of various organic compounds. Its unique functional groups allow it to participate in a variety of chemical reactions, making it a valuable component in the creation of pharmaceuticals, agrochemicals, or other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Cyano-N-(4-sulfamoyl-phenyl)-acetamide is used as a building block for the development of new drugs. Its specific structural features may contribute to the design of molecules with potential therapeutic properties, such as antimicrobial, antiviral, or anticancer activities.
Used in Agrochemical Industry:
2-Cyano-N-(4-sulfamoyl-phenyl)-acetamide is utilized as a precursor in the synthesis of agrochemicals, such as pesticides or herbicides. Its chemical properties may be harnessed to create compounds that effectively control pests or weeds, thereby enhancing crop protection and yield.
Used in Research and Development:
In the field of research and development, 2-Cyano-N-(4-sulfamoyl-phenyl)-acetamide serves as a versatile compound for exploring new chemical reactions and understanding the behavior of various functional groups. Its unique structure makes it an interesting subject for academic and industrial research, potentially leading to the discovery of new applications and products.

InChI:InChI=1/C9H9N3O3S/c10-6-5-9(13)12-7-1-3-8(4-2-7)16(11,14)15/h1-4H,5H2,(H,12,13)(H2,11,14,15)

Upstream product

• 63-74-1 sulfanilamide 
• 36140-83-7 1-cyanoacetyl-3,5-dimethylpyrazole 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 69568-33-8 2-amino-N-[4-(aminosulfonyl)phenyl]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide 
• 83822-32-6 4-(4-Oxo-5,6,7,8-tetrahydro-4H-benzo[4,5]thieno[2,3-d]pyrimidin-3-yl)-benzenesulfonamide 
• 1224956-98-2 2-cyano-N-(4-sulfamoylphenyl)-3,3-bis(methylsulfanyl)acrylamide 
• 1224957-00-9 2-cyano-3-methylsulfanyl-3-phenylamino-N-(4-sulfamoylphenyl)acrylamide 
• 1426537-65-6 2-oxo-N’-phenyl-2-(4-sulfamoylphenylamino)acetohydrazonoyl cyanide 
• 667413-56-1 3-(2-chlorophenyl)-2-cyano-N-(4-sulfamoylphenyl)acrylamide 
• 333307-40-7 2-cyano-3-(2,4-dichlorophenyl)-N-(4-sulfamoylphenyl)acrylamide 
• 492443-21-7 2-cyano-3-(4-nitrophenyl)-N-(4-sulfamoylphenyl)acrylamide 
• 333307-23-6 2-cyano-3-(2-methoxyphenyl)-N-(4-sulfamoylphenyl)acrylamide 
• 464195-95-7 2-cyano-3-(4-methoxyphenyl)-N-(4-sulfamoylphenyl)acrylamide 
• 904201-02-1 2-cyano-N-(4-sulfamoylphenyl)-3-(3,4,5-trimethoxyphenyl)acrylamide 
• 889230-69-7 2-cyano-N-(4-sulfamoylphenyl)-3-(2,4,5-trimethoxyphenyl)acrylamide 
• 1426537-64-5 2-cyano-N-(4-sulfamoylphenyl)-3-(2,4,6-trimethoxyphenyl)acrylamide 
• 333307-31-6 2-cyano-3-(3,4-dimethoxyphenyl)-N-(4-sulfamoylphenyl)acrylamide 

Relevant academic research and scientific papers

Synthesis and Antioxidant Evaluation of Some Novel Thiophene, Pyrazole, Chromene, Pyrazolotriazine Derivatives Bearing Sulfonamide Moiety

As a part of ongoing studies in developing new potent antioxidant agents, N-[4-(aminosulfonyl)phenyl]-2-cyanoacetamide (3) was utilized as key intermediate for the synthesis of some new thiophene, chromene, and pyrazolotriazine pyridine derivatives. The structures of the newly synthesized compounds were confirmed by elemental analysis, IR,1H-NMR, and mass spectral data. Representative compounds of the synthesized products were tested and evaluated as antioxidant. Compounds 7 and 30 are promising compounds.

Synthesis and anti-oxidant evaluation of some novel sulfa drugs

Background: Curcumins were reported to possess anti-inflammatory and antiangiogenic. Furthermore, Curcumin is a very potent free radical scavenger than vitamin E. Moreover, cyanoacetamides were reported to possess, antimicrobial antifungal, insulin releasing, antiinflammatory and antitumor. Thus the present study focuses on the synthesis of some novel structure hybrids incorporating either curcumin or cyanoacetamide with sulphonamide, aiming to reach a more potent antioxidant agent. Methods: 4-arylazoenol derivatives 12-16 and E-hydrazo derivatives 19-23 were prepared and their structure was confirmed by variable spectra analysis. The newly synthesized compounds were screened for their antioxidant activity using ABTS and Bleomycin-dependent DNA damage methods. Results: Coupling of the diazonium salts 7-11 of different sulpha drugs with curcumin 1 or with cyanoacetamide 18 afforded the corresponding 4-arylazoenol derivatives 12-16 and E-hydrazo derivatives 19-23. Among all the synthesized compounds, 12-16, 18, 20 and 22 were the most potent antioxidant compounds. Conclusion: The objective of the present study was to synthesize and evaluate the antioxidant activity of some novel sulfonamides structure hybrids incorporating either curcumin or N-[4- (aminosulfonyl) phenyl]-2-cyanoacetamide moiety with the hope of discovering new structure serving as antioxidant agent. The data showed clearly that most of compounds displayed good in vitro antioxidant activities.

Cyanoacetanilides intermediates in heterocyclic synthesis. Part 5: Preparation of hitherto unknown 5-aminopyrazole and pyrazolo[1,5-a]pyrimidine derivatives containing sulfamoyl moiety

Novel 5-aminopyrazole and pyrazolo[1,5-a]pyrimidine derivatives have been synthesized from the readily accessible cyanoacetanilide derivative (2).

Cyanoacetanilides intermediates in heterocyclic synthesis. Part 4: Preparation of some hitherto unknown thiazolidine and bisthiazolidine derivatives

Some novel thiazolidine and bisthiazolidine derivatives were synthesized from the reaction of cyanoacetanilide derivative (2) with isothiocyanates in the presence of potassium hydroxide followed by in situ heterocyclization of the resulting adducts with various α-halogenated reagents. Copyright Taylor & Francis Group, LLC.