32951-76-1Relevant academic research and scientific papers
Synthesis of monomeric and dimeric acridine compounds as potential therapeutics in Alzheimer and prion diseases
Csuk, Rene,Barthel, Alexander,Raschke, Christian,Kluge, Ralph,Stroehl, Dieter,Trieschmann, Lothar,Boehm, Gerald
, p. 699 - 709 (2009)
Starting from substituted 9-chloroacridines, a series of quinacrine and spacered dimeric acridine compounds was prepared. Their ability to interrupt the protein association of prion- and Alzheimer-specific proteins and Ab peptides was explored using a fast screening system based on FACS analysis. The bis-acridines displayed a higher activity than the corresponding monomers. Among these derivatives, best results were obtained with the 2,4-dimethoxy-6-nitro compound 7h for Aβ-peptides and the 2-methoxy-6-nitro compound 7f for PrP.
