32955-22-9

Basic information

• Product Name: Ethyl thiazole-5-carboxylate
• Synonyms: RARECHEM AL BI 1261;ETHYL THIAZOLE-5-CARBOXYLATE;ETHYL 1,3-THIAZOLE-5-CARBOXYLATE;Ethyl 1,3-thiazole-5-carboxylate 98%;5-Thiazolecarboxylic acid, ethyl ester;Thiazole-5-carboxylic acid ethyl ester;Ethyl 5-thiazolecarboxylate;5-(Ethoxycarbonyl)-1,3-thiazole
• CAS NO: 32955-22-9
• Molecular Formula: C₆H₇NO₂S
• Molecular Weight: 157.19
• Product Categories: blocks;Carboxes;Thiazoles
• Mol File: 32955-22-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 235.7 °C at 760 mmHg
• Flash Point: 96.4 °C
• Appearance: /
• Density: 1.242 g/cm³
• Vapor Pressure: 0.0492mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: Keep Cold
• PKA: 0.90±0.10(Predicted)
• CAS DataBase Reference: Ethyl thiazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl thiazole-5-carboxylate(32955-22-9)
• EPA Substance Registry System: Ethyl thiazole-5-carboxylate(32955-22-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 32955-22-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 5939, 1984 DOI: 10.1016/S0040-4039(01)81726-3

InChI:InChI=1/C6H7NO2S/c1-2-9-6(8)5-3-7-4-10-5/h3-4H,2H2,1H3

Upstream product

• 77287-34-4 formamide 
• 33142-21-1 ethyl 2-chloro-3-oxopropanoate 
• 115-08-2 thiocarboxamide 
• 188290-36-0 thiophene 
• 83553-48-4 ethyl 2-iodothiazole-5-carboxylate 
• 32955-21-8 2-amino-thiazole-5-carboxylic acid ethyl ester 
• 110-46-3 isopentyl nitrite 
• 3034-55-7 5-bromo-1,3-thiazole 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 

Downstream Products

• 14527-41-4 thiazole-5-carboxylic acid 
• 74411-19-1 thiazole-5-carboxamide 
• 38585-74-9 thiazol-5-yl-methanol 

Relevant articles and documents

Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120

In our attempt to optimize the lead HIV-1 entry antagonist, NBD-11021, we present in this study the rational design and synthesis of 60 new analogues and determination of their antiviral activity in a single-cycle and a multicycle infection assay to derive a comprehensive structure-activity relationship (SAR). Two of these compounds, NBD-14088 and NBD-14107, showed significant improvement in antiviral activity compared to the lead entry antagonist in a single-cycle assay against a large panel of Env-pseudotyped viruses. The X-ray structure of a similar compound, NBD-14010, confirmed the binding mode of the newly designed compounds. The in vitro ADMET profiles of these compounds are comparable to that of the most potent attachment inhibitor BMS-626529, a prodrug of which is currently undergoing phase III clinical trials. The systematic study presented here is expected to pave the way for improving the potency, toxicity, and ADMET profile of this series of compounds with the potential to be moved to the early preclinical development.

Tandem photoarylation-photoisomerization of halothiazoles: Synthesis, photophysical and singlet oxygen activation properties of ethyl 2-arylthiazole-5-carboxylates

The photochemical reaction between ethyl 2-chlorothiazole5-carboxylate and benzene gave no product. In contrast, the reaction with ethyl 2-iodothiazole-5-carboxylate gave ethyl 3-phenylisothiazole-4-carboxylate. The same behaviour was observed if the reac

RETROVIRAL PROTEASE INHIBITING COMPOUNDS

A compound of the formula: STR1 is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.