32973-53-8

Usage

Molecular Weight

255.35 g/mol The mass of one mole of the compound, based on the atomic weights of the elements present.

Structure

2-(1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanol A structural formula showing the arrangement of atoms in the compound and the functional groups present.

Family

Isoquinolines A group of organic compounds to which the compound belongs, characterized by a specific chemical structure.

Derivative

Isoquinoline with an added alcohol functional group The compound is derived from isoquinoline by adding an alcohol group, which modifies its chemical properties.

Pharmacological Properties

Potential applications in medicine and drug development The compound has properties that may be relevant to the treatment or management of diseases and conditions, but further research is needed to confirm its potential uses and effects.

InChI:InChI=1/C17H19NO/c19-13-12-18-11-10-14-6-4-5-9-16(14)17(18)15-7-2-1-3-8-15/h1-9,17,19H,10-13H2

Upstream product

• 75-21-8 oxirane 
• 22990-19-8 1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 52250-50-7 1-phenyl-3,4-dihydroisoquinoline 

Relevant academic research and scientific papers

Dopamine/serotonin receptor ligands. 10: SAR studies on azecine-type dopamine receptor ligands by functional screening at human cloned D1, D2L, and D5 receptors with a microplate reader based calcium assay lead to a novel potent D1/D5 selective antagonist

On the basis of the benz[d]indolo[2,3-g]azecine derivative 1 (LE300), structure-activity relations were investigated in order to identify the pharmacophore in this new class of ligands. Various structural modifications were performed and the inhibitory activities at human cloned D1, D2L, and D5 receptors were measured by using a simple fluorescence microplate reader based calcium assay. Subsequently, the affinities of active compounds were estimated by radioligand binding experiments, Deleting one of the aromatic rings as well as replacing it by a phenyl moiety abolishes the inhibitory activities almost completely. Contraction of the 10-membered central ring decreases them significantly. The replacement of indole by thiophene or N-methylpyrrole reduces the inhibitory activity, whereas replacing the indole by benzene increases it. Finally, the hydroxylated dibenz[d,g]azecine derivative 11d (LE404) was found to be more active than the lead 1 in the functional calcium assay as well as in radioligand displacement experiments.

BENZO- AND INDOLOQUINOLIZINE DERIVATIVES XX. SYNTHESIS AND CONFORMATION OF 5,6,8,9-TETRAHYDRO-13bH-DIBENZOQUINOLIZINE AND 5,6,8,9,14,14b-HEXAHYDROBENZOINDOLOQUINOLIZINE.

Dibenzoquinolizidines are prepared by an imminium cyclization or by PPA cyclization of the ethyleneoxide adduct of 1,2,3,4-tetrahydro-1-phenylisoquinoline.The conformational equilibrium in the title compounds is studied by 13C NMR.