329796-14-7Relevant academic research and scientific papers
Three-component uncatalyzed eco-friendly reactions for one-pot synthesis of 4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine derivatives
El Rady, Eman A.
, p. 869 - 875 (2014)
A three-component system of one-pot synthesis of [1,2,4]triazolo[1,5-a] pyrimidine derivatives using condensation of 1,3-dicarbonyl compounds, aldehydes, and 5-amino[1,2,4]triazole in ethanol without any catalyst was reported in high yields via simple, efficient, and environmentally friendly process. The method reported herein considered a green process; this method has significant advantages of simple workup procedure, excellent yield, minimal environmental pollution, and short reaction time over classical reported methods.
Alkylation of 6-C(O)R-7-aryl-5-methyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidines
Kolosov, Maksim A.,Shvets, Elena H.,Kulyk, Olesia G.,Orlov, Valeriy D.
, p. 1052 - 1056 (2016/08/26)
Alkylation of 6-C(O)R-7-aryl-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidines with methyl iodide or ethyl bromide in either saturated aqueous KOH–MeCN or NaH–DMF led to the formation of N4-alkyl derivatives in good yields (60–98%). Reactivity of the acetyl group of N4-alkyl derivatives towards aromatic aldehydes under the conditions of the Claisen–Schmidt reaction was significantly higher than in 4-unsubstituted compounds. The starting 6-C(O)R-7-aryl-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidines were synthesized via a three-component condensation of an aromatic aldehyde, 3-amino-1,2,4-triazole, and a dicarbonyl compound (2,4-pentanedione or ethyl acetoacetate) in DMF.
