3298-16-6

Usage

Uses

Used in Pharmaceutical Industry:
5-METHYL-2-PIPERIDINONE is used as a precursor in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and active ingredients. Its unique chemical structure allows for the creation of a wide range of medicinal compounds, enhancing the therapeutic potential of various treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 5-METHYL-2-PIPERIDINONE is utilized as a starting material for the production of agrochemicals, such as pesticides and herbicides. Its role in the synthesis of these compounds helps to improve crop protection and increase agricultural productivity.
Used in Polymer Industry:
5-METHYL-2-PIPERIDINONE is employed as a monomer or a building block in the production of polymers. Its incorporation into polymer chains contributes to the development of materials with specific properties, such as improved strength, flexibility, or chemical resistance, which are essential for various applications.
Used in Dye Industry:
In the dye industry, 5-METHYL-2-PIPERIDINONE is used as a key intermediate in the synthesis of dyes and pigments. Its presence in these colorants allows for the creation of a diverse range of hues and shades, catering to the needs of various industries, such as textiles, plastics, and printing.
Used in Surfactant Industry:
5-METHYL-2-PIPERIDINONE is utilized in the production of surfactants, which are essential components in a wide range of consumer and industrial products. Its role in the synthesis of these compounds contributes to the development of surfactants with specific properties, such as improved solubility, emulsification, or foaming characteristics.
Used in Industrial and Consumer Products:
5-METHYL-2-PIPERIDINONE can be found in various industrial and consumer products, such as adhesives, coatings, and cleaning agents. Its presence in these products enhances their performance and contributes to their overall effectiveness, making it an indispensable component in their formulation.

Upstream product

• 626-56-2 3-Methylpiperidine 
• 74-89-5 methylamine 
• 29553-51-3 3-methyl-piperidine-2,6-dione 

Relevant academic research and scientific papers

PROCESS FOR PREPARING LACTAMS

The present invention relates to a method for preparing lactams using heterogeneous catalysis by hydrogenating at least one compound of the following formula (I), where A is a radical of the following formula (I′) or (II′): —CH(R1)—CH(R2)— (I′); or —CH(R1)—CH(R2)—CH(R3)— (II′); where R1, R2 and R3 are, independently from each other, H, OH, an alkyl radical, or a cycloalkyl radical; and R is H or a straight or branched alkyl radical having 1 to 20, preferably 1 to 10, and more preferably 1 to 4 carbon atoms. Said method is carried out at a pressure of less than 60 bars, preferably 10 to 50 bars, in the presence of a solid hydrogenation catalyst including at least two metals selected from the group of noble metals and transition metals, and an inert substance used as a support, wherein said compound of formula (I) can be used alone or as part of a mixture.

Oxidant-free conversion of cyclic amines to lactams and H2 using water as the oxygen atom source

Direct conversion of cyclic amines to lactams utilizing water as the only reagent is catalyzed by pincer complex 2. In contrast to previously known methods of amine-to-amide conversion, this reaction occurs in the absence of oxidants and is accompanied by liberation of H2, with water serving as a source of oxygen atom. Formation of a cyclic hemiaminal intermediate plays a key role in enabling such reactivity. This represents an unprecedented, conceptually new type of amide formation reaction directly from amines and water under oxidant-free conditions.

Chemoenzymic Production of Lactams from Aliphatic α,ω-Dinitriles

Five- and six-membered ring lactams have been prepared by first converting an aliphatic α,ω-dinitrile to an ω-cyanocarboxylic acid ammonium salt, using a microbial cell catalyst having an aliphatic nitrilase activity (Acidovorax facilis 72W, ATCC 55746) or a combination of nitrile hydratase and amidase activities (Comamonas testosteroni 5-MGAM-4D, ATCC 55744). The ω-cyanocarboxylic acid ammonium salt was then directly converted to the corresponding lactam by hydrogenation in aqueous solution, without isolation of the intermediate ω-cyanocarboxylic acid or ω-aminocarboxylic acid. Only one of two possible lactam products was produced from α-alkyl-substituted α,ω-dinitriles, where the nitrilase of A. facilis 72W regioselectively hydrolyzed only the ω-cyano group to produce a single cyanocarboxylic acid ammonium salt in greater than 98% yield.

PREPARATION OF LACTAMS VIA OXIDATION OF CYCLIC, TERTIARY AND SECONDARY AMINES WITH Hg(II)-EDTA COMPLEX IN ALKALINE MEDIUM

Oxidation of N-alkylpiperidines and other cyclic, tertiary amines with Hg(II)-EDTA complex in basic solution yields lactams, similar oxidation of N-hydroxypiperidines gives hydroxamic acids (presumably via nitrones) and oxidation of N-unsubstituted piperidines affords lactams, probably via 1-piperidine trimers.