32981-90-1

Basic information

• Product Name: ACETYLBACCATIN III, 7-(P)
• Synonyms: ACETYLBACCATIN III, 7-(P);BACCATIN III(P);7-Acety Baccatin III
• CAS NO: 32981-90-1
• Molecular Formula: C₃₃H₄₀O₁₂
• Molecular Weight: 628.66
• Mol File: 32981-90-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ACETYLBACCATIN III, 7-(P)(CAS DataBase Reference)
• NIST Chemistry Reference: ACETYLBACCATIN III, 7-(P)(32981-90-1)
• EPA Substance Registry System: ACETYLBACCATIN III, 7-(P)(32981-90-1)

Safety Data

• Hazardous Substances Data: 32981-90-1(Hazardous Substances Data)

Usage

General Description

Acetylbacatin III, 7-(P) is a chemical compound that is a derivative of the natural product Baccatin III, commonly found in yew trees. Acetylbacatin III, 7-(P) has pharmaceutical importance as it is a key precursor in the semisynthesis of taxol, a widely used anticancer drug. It is used as a starting material for the synthesis of various taxane compounds which have demonstrated potent antitumor activity. Acetylbacatin III, 7-(P) is an important intermediate in the production of taxol and other taxane derivatives, making it a valuable compound in the pharmaceutical industry.

Upstream product

• 32981-86-5 10-deacetylbaccatin III 
• 108-24-7 acetic anhydride 
• 92950-44-2 7,13-diacetyl baccatin III 
• 27548-93-2 baccatin III 

Downstream Products

• 32981-86-5 10-deacetylbaccatin III 
• 32981-91-2 7-O-acetyl-13-oxobaccatin III 
• 913331-47-2 C₅₀H₆₁NO₁₆ 
• 92950-39-5 7-acetylpaclitaxel 
• 81924-74-5 2',7-bis-acetyltaxol 

Relevant articles and documents

Method for preparing 7-acetyl paclitaxel

The invention discloses a method for preparing 7-acetyl paclitaxel. The method comprises the following steps: 1, acetylizing the seventh position and the tenth position of 10-Dab used as a raw material to prepare an intermediate 1; 2, carrying out a conde

Silver-mediated oxidative aliphatic C-H trifluoromethylthiolation

The first example of a practical and direct trifluoromethylthiolation reaction of unactivated aliphatic C-H bonds employs a silver-based reagent. The reaction is operationally simple, scalable, and proceeds under aqueous conditions in air. Furthermore, its broad scope and good functional-group compatibility were demonstrated by applying this method to the selective trifluoromethylthiolation of natural products and natural-product derivatives.

CONVERSION 9-DIHYDRO-13-ACETYLBACCATIN III TO 10-DEACETYLBACCATIN III

The present invention relates to a process is provided for the conversion of 9-dihydro-13-acetylbaccatin to 10-deacetylbaccatin III. The process includes four specific interrelated steps. The first step involves protecting the 7-hydroxyl group of 9-dihydro-13-acetylbaccatin and converting that 7-hydroxyl-protected 9-dihydro-13-acetylbaccatin to 7, 13-diacetyl-9-dihydrobaccatin III. The second step involves reacting that 7, 13-diacetyl-9-dihydrobaccatin III with 4-methylmorpholine N-oxide in a suitable solvent and oxidizing that reaction product to yield 7, 13-diacetylbaccatin. The third step involves deacetylating that 7, 13-diacetyl-9-dihydrobaccatin III to yield 7-acetylbaccatin III. The fourth and final step involves converting that 7-acetylbaccatin III to 10-deacetylbaccatin III.