32987-10-3Relevant academic research and scientific papers
A Dipolar Cycloaddition Reaction to Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate
Chrovian, Christa C.,Soyode-Johnson, Akinola,Peterson, Alexander A.,Gelin, Christine F.,Deng, Xiaohu,Dvorak, Curt A.,Carruthers, Nicholas I.,Lord, Brian,Fraser, Ian,Aluisio, Leah,Coe, Kevin J.,Scott, Brian,Koudriakova, Tatiana,Schoetens, Freddy,Sepassi, Kia,Gallacher, David J.,Bhattacharya, Anindya,Letavic, Michael A.
, p. 207 - 223 (2018/02/10)
A single pot dipolar cycloaddition reaction/Cope elimination sequence was developed to access novel 1,4,6,7-tetrahydro-5H-[1,2,3]triazolo[4,5-c]pyridine P2X7 antagonists that contain a synthetically challenging chiral center. The structure-activity relati
Organocatalytic 1,3-dipolar cycloaddition reactions of ketones and azides with water as a solvent
Yeung, Dwun Kit Jonathan,Gao, Tao,Huang, Jiayao,Sun, Shaofa,Guo, Haibing,Wang, Jian
, p. 2384 - 2388 (2013/09/12)
We reported an enamine catalyzed strategy to fully promote a 1,3-dipolar cycloaddition to access a vast pool of substituted 1,2,3-triazoles with water as the only solvent.
Amine-catalyzed [3+2] Huisgen cycloaddition strategy for the efficient assembly of highly substituted 1,2,3-triazoles
Wang, Lei,Peng, Shiyong,Danence, Lee Jin Tu,Gao, Yaojun,Wang, Jian
supporting information; experimental part, p. 6088 - 6093 (2012/07/01)
An enamine-catalyzed strategy has been utilized to fully promote the Huisgen [3+2] cycloaddition with a broad spectrum of carbonyl compounds and azides, thereby permitting the efficient assembly of a vast pool of highly substituted 1,2,3-triazoles. In par
Organocatalytic synthesis of 1,2,3-triazoles from unactivated ketones and arylazides
Belkheira, Mokhtaria,El Abed, Douniazad,Pons, Jean-Marc,Bressy, Cyril
supporting information; experimental part, p. 12917 - 12921 (2011/12/04)
Organo-click reaction: A new and complementary method to Huisgen's metal-catalyzed triazole synthesis is described using unactivated ketones and arylazides as the substrates and proline as an organocatalyst. Dramatic acceleration was observed for this reaction using microwave activation and high regio- and chemoselectivities were obtained for a wide range of ketones and arylazides (see scheme). Copyright
Bi-3H-diazirin-3-yls as precursors of highly strained cycloalkynes
Al-Omari, Mohammad,Banert, Klaus,Hagedorn, Manfred
, p. 309 - 311 (2007/10/03)
(Chemical Equation Presented) No reagents and very mild conditions are required for the transformation of isolable precursors 3 into highly strained cycloalkynes 4 (cycloheptyne, cyclohexyne, norbornyne), which can be trapped by cycloaddition reactions.
