3299-46-5

Basic information

• Product Name: 6-CHLORO-3-ETHYL-2-PROPYL-QUINOLINE
• Synonyms: 6-CHLORO-3-ETHYL-2-PROPYL-QUINOLINE
• CAS NO: 3299-46-5
• Molecular Formula: C₁₄H₁₆ClN
• Molecular Weight: 233.73654
• Mol File: 3299-46-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 323.5°C at 760 mmHg
• Flash Point: 179.1°C
• Appearance: /
• Density: 1.108g/cm³
• Vapor Pressure: 0.000493mmHg at 25°C
• Refractive Index: 1.586
• PKA: 5.20±0.50(Predicted)
• CAS DataBase Reference: 6-CHLORO-3-ETHYL-2-PROPYL-QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-3-ETHYL-2-PROPYL-QUINOLINE(3299-46-5)
• EPA Substance Registry System: 6-CHLORO-3-ETHYL-2-PROPYL-QUINOLINE(3299-46-5)

Safety Data

• Hazardous Substances Data: 3299-46-5(Hazardous Substances Data)

Usage

Structure

A quinoline derivative with a chlorine atom at the 6th position, an ethyl group at the 3rd position, and a propyl group at the 2nd position

Common uses

Building block in the synthesis of pharmaceuticals and agrochemicals

Applications

Development of antimalarial, antifungal, and antibacterial medications

Additional uses

Reagent in organic synthesis, intermediate in the production of various chemical products

InChI:InChI=1/C14H16ClN/c1-3-5-13-10(4-2)8-11-9-12(15)6-7-14(11)16-13/h6-9H,3-5H2,1-2H3

Upstream product

• 106-47-8 4-chloro-aniline 
• 123-72-8 butyraldehyde 
• 102-82-9 tributyl-amine 
• 100-00-5 4-chlorobenzonitrile 

Relevant articles and documents

Synthesis of quinoline derivatives from anilines and aldehydes catalyzed by Cp2ZrCl2 and recyclable Cp2ZrCl2/MCM-41 system

A facile method for the synthesis of quinoline derivatives using catalytic amount of Cp2ZrCl2 or Cp2ZrCl2 supported on MCM-41 (Cp2ZrCl2/MCM-41) in reaction of anilines and aldehydes is described. When Cp2ZrCl2/MCM-41 was used as catalyst, the yields of quinolines were enhanced by 5-15% compared with Cp2ZrCl2 as catalyst alone under the same reaction conditions. More importantly, Cp2ZrCl2/MCM-41 catalyst can be reused at least thrice by simple recover via filtration in air. Moreover, both Cp2ZrCl2 and Cp2ZrCl2/MCM-41 showed good catalytic activities to generate corresponding quinoline derivatives in moderate to good yields by varying the substituent of aniline and aldehyde. And the reaction conditions were optimized by studying the influences of reactant ratio, additives, solvent effect and reaction temperatures.

Synthesis of quinolines via ruthenium-catalysed amine exchange reaction between anilines and trialkylamines

Anilines react with an array of trialkylamines in the presence of a catalytic amount of RuCl3*nH2O and bis(diphenylphosphino)methane together with SnCl2*2H2O and hex-1-ene as hydrogen acceptor in dioxane at 180 deg C to afford the corresponding 2,3-disubstituted quinolines in moderate to good yields.