329901-78-2

Basic information

• Product Name: (R)-N-[4-chlorosulphonyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
• Synonyms: (R)-N-[4-chlorosulphonyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
• CAS NO: 329901-78-2
• Molecular Weight: 492.042
• Mol File: 329901-78-2.mol

Chemical Properties

• CAS DataBase Reference: (R)-N-[4-chlorosulphonyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-[4-chlorosulphonyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide(329901-78-2)
• EPA Substance Registry System: (R)-N-[4-chlorosulphonyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide(329901-78-2)

Safety Data

• Hazardous Substances Data: 329901-78-2(Hazardous Substances Data)

Upstream product

• 329901-79-3 (R)-N-[3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 
• 3970-41-0 2-chloro-3-nitroaniline 
• 329901-81-7 (R)-N-(3-nitro-2-chlorophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 
• 329901-80-6 (R)-N-[3-amino-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 

Downstream Products

• 329926-70-7 (R)-N-[4-mercapto-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 
• 329926-69-4 (R)-N-[4-Ethylsulphanyl-3-iodo-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 

Relevant articles and documents

Substituted N-phenyl 2-hydroxy-2-methyl-3,3,3-trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity

A compound of formula (I) wherein: n is 1 or 2; R 1 is chloro, fluoro, bromo, methyl or methoxy; R 2 is as defined within; R 3 is as defined within; and R 4 is hydrogen or fluoro; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed. STR1

Chemical compounds

A compound of formula (I) wherein: R1, R2, R3, R4, R5, R6and R7are as defined within; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.