329904-04-3Relevant academic research and scientific papers
Ratiometric detection of adenosine-5'-triphosphate (ATP) and cytidine-5'-triphosphate (CTP) with a fluorescent spider-like receptor in water
Gupta, Abhishek Kumar,Dhir, Abhimanew,Pradeep, Chullikkattil P.
, p. 122 - 129 (2015)
A series of water-soluble spider-like receptor molecules has been developed by the Schiff-base condensation of tris-(hydroxymethyl)aminomethane (TRIS) with various 2,6-diformylphenol (dfp) derivatives. The products were assessed for their anion sensing properties. Among these, the receptor with a methoxy substituent showed selective fluorescent sensing towards adenosine-5'-triphosphate (ATP) and cytidine-5'-triphosphate (CTP) in contrasting modes in 100% aqueous media at pH 7.2.
A trinuclear copper (II) complex derived from a chiral [3 + 3] phenol-based macrocycle: Synthesis, structure and magnetic properties
Cheng, Lin,Wang, Jun,Zhang, Xiu-Ying,Gou, Shao-Hua,Fang, Lei
, p. 144 - 147 (2014)
An enantiopure trinuclear Cu(II) complex of chiral phenol-based macrocyclic polyamine ligand, which is derived from the [3 + 3] condensation of 3,5-diformyl-4-hydroxyzoic acid ethyl ester with (1R,2R)-1,2-diaminocyclohexane and followed by borohydride reduction, has been synthesized and characterized. The circular dichroism (CD) spectra confirmed its structural chirality in the bulk sample. Variable temperature magnetic data indicated that there is an antiferromagnetic coupling between the metal centers in the complex.
Examination of structure-activity relationship of new n-acylhydrazones
Coman, Anca G.,Paun, Anca,Popescu, Codru?a C.,Hadade, Niculina D.,Hanganu, Anamaria,M?d?lan, Augustin M.,Matache, Mihaela
, p. 109 - 114 (2021/02/05)
In this study we describe synthesis and characterization of new substituted hydroxy-bis-N-acylhydrazones in order to investigate influence of their switching emission properties, according to the nature of the substituent. The fluorescence of the compounds depended on the solvent used (organic or aqueous). The different emission colors observed could be explained by conformation modifications.
Examination of structure-activity relationship of new n-acylhydrazones
Coman, Anca G.,Hadade, Niculina D.,Hanganu, Anamaria,Mǎdǎlan, Augustin M.,Matache, Mihaela,Paun, Anca,Popescu, Codru?a C.
, p. 109 - 114 (2020/07/23)
In this study we describe synthesis and characterization of new substituted hydroxy-bis-N-acylhydrazones in order to investigate influence of their switching emission properties, according to the nature of the substituent. The fluorescence of the compounds depended on the solvent used (organic or aqueous). The different emission colors observed could be explained by conformation modifications.
donor-two-acceptor dye design: A distinct gateway to NIR fluorescence
Karton-Lifshin, Naama,Albertazzi, Lorenzo,Bendikov, Michael,Baran, Phil S.,Shabat, Doron
supporting information, p. 20412 - 20420 (2013/02/25)
The detection of chemical or biological analytes upon molecular reactions relies increasingly on fluorescence methods, and there is a demand for more sensitive, more specific, and more versatile fluorescent molecules. We have designed long wavelength fluorogenic probes with a turn-ON mechanism based on a donor-two-acceptor π-electron system that can undergo an internal charge transfer to form new fluorochromes with longer π-electron systems. Several latent donors and multiple acceptor molecules were incorporated into the probe modular structure to generate versatile dye compounds. This new library of dyes had fluorescence emission in the near-infrared (NIR) region. Computational studies reproduced the observed experimental trends well and suggest factors responsible for high fluorescence of the donor-two-acceptor active form and the low fluorescence observed from the latent form. Confocal images of HeLa cells indicate a lysosomal penetration pathway of a selected dye. The ability of these dyes to emit NIR fluorescence through a turn-ON activation mechanism makes them promising candidate probes for in vivo imaging applications.
ACTIVATABLE FLUOROGENIC COMPOUNDS AND USES THEREOF AS NEAR INFRARED PROBES
-
Page/Page column 71, (2012/10/07)
Novel fluorogenic compounds designed such that upon a chemical event, compounds capable of emitting NIR light are generated, are disclosed. The compounds comprise two or more acceptor-containing moieties and a cleavable donor-containing moiety, being in c
Discovery of novel small molecule inhibitors of dengue viral NS2B-NS3 protease using virtual screening and scaffold hopping
Deng, Jing,Li, Ning,Liu, Hongchuan,Zuo, Zhili,Liew, Oi Wah,Xu, Weijun,Chen, Gang,Tong, Xiankun,Tang, Wei,Zhu, Jin,Zuo, Jianping,Jiang, Hualiang,Yang, Cai-Guang,Li, Jian,Zhu, Weiliang
, p. 6278 - 6293 (2012/09/07)
By virtual screening, compound 1 was found to be active against NS2B-NS3 protease (IC50 = 13.12 ± 1.03 μM). Fourteen derivatives (22) of compound 1 were synthesized, leading to the discovery of four new inhibitors with biological activity. In order to expand the chemical diversity of the inhibitors, small-molecule-based scaffold hopping was performed on the basis of the common scaffold of compounds 1 and 22. Twenty-one new compounds (23, 24) containing quinoline (new scaffold) were designed and synthesized. Protease inhibition assays revealed that 12 compounds with the new scaffold are inhibitors of NS2B-NS3 protease. Taken together, 17 new compounds were discovered as NS2B-NS3 protease inhibitors with IC50 values of 7.46 ± 1.15 to 48.59 ± 3.46 μM, and 8 compounds belonging to two different scaffolds are active to some extent against DENV based on luciferase reporter replicon-based assays. These novel chemical entities could serve as lead structures for discovering therapies against DENV.
