329938-69-4Relevant academic research and scientific papers
Direct amide synthesis: via Ni-mediated aminocarbonylation of arylboronic acids with CO and nitroarenes
Shen, Ni,Cheung, Chi Wai,Ma, Jun-An
, p. 13709 - 13712 (2019)
Herein we describe an alternative and unconventional approach of an aminocarbonylation reaction to access aryl amides from readily available and low-cost arylboronic acids and nitroarenes. Nickel metal can serve as both reductant and catalyst in this direct aminocarbonylation. This protocol exhibits a good functional group compatibility and allows a variety of aryl amides to be synthesized, including several drug-like molecules.
