329966-94-1Relevant academic research and scientific papers
Aminosuberoyl hydroxamic acids (ASHAs): A potent new class of HDAC inhibitors
Belvedere, Sandro,Witter, David J.,Yan, Jiaming,Secrist, J. Paul,Richon, Victoria,Miller, Thomas A.
, p. 3969 - 3971 (2007)
Histone deacetylase (HDAC) inhibitors that target Class I and Class II HDACs are currently in advanced clinical trials for the treatment of cancer. Vorinostat (Zolinza, SAHA) is a hydroxamic acid approved for the treatment of patients with cutaneous T-cel
Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitors
Taddei, Maurizio,Cini, Elena,Giannotti, Luca,Giannini, Giuseppe,Battistuzzi, Gianfranco,Vignola, Davide,Vesci, Loredana,Cabri, Walter
, p. 61 - 64 (2014)
A series of SAHA-like molecules were prepared introducing different lactam-carboxyamides in position 7 of the suberoylanilide skeleton. The activity against different HDAC isoforms was tested and the data compared with the corresponding linear products, w
Derivatives of 1-amino-1-(hetero)arylaminocarbonyl-6-hydroxyaminocarbonylhexane useful in the treatment of tumors
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Paragraph 0048; 0049, (2015/11/11)
The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkyloxy, or pyr
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite
Giannini, Giuseppe,Battistuzzi, Gianfranco,Vignola, Davide
, p. 459 - 461 (2015/01/30)
Recent studies have highlighted a key role in regulating gene transcription, in both eukaryotes and prokaryotes, by enzymes that control the acetylation and deacetylation of histones. In particular, inhibitors of histone deacetylases (HDAC-Is) have been s
HISTONE DEACETYLASE INHIBITORS
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Page/Page column 51-52, (2008/06/13)
This invention relates to hydroxamic acid derivatives having a urea linkage, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic
HISTONE DEACETYLASE INHIBITORS
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Page/Page column 49, (2008/06/13)
This invention relates to hydroxamic acid derivatives having a carbamate linkage, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, alle
HISTONE DEACETYLASE INHIBITORS
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Page/Page column 51, (2008/06/13)
This invention relates to hydroxamic acid derivatives having a sulfonamide linkage, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, al
