330-41-6Relevant academic research and scientific papers
Pd/C-catalyzed reductive carbonylation of nitroaromatics for the synthesis of unsymmetrical ureas: One-step synthesis of neburon
Li, Chong-Liang,Peng, Jin-Bao,Qi, Xinxin,Ying, Jun,Wu, Xiao-Feng
supporting information, p. 12472 - 12475 (2018/08/04)
A Pd/C catalyzed reductive carbonylation of nitroarenes for the synthesis of unsymmetrical ureas has been developed. Using inexpensive and stable nitroarenes as the substrates, a series of unsymmetrical ureas were produced in moderate to good yields. A range of functional groups including thioethers, halides and vinyl were compatible with this reaction. As a heterogeneous catalyst, Pd/C was recycled and reused four times without losing activity. Notably, urea-based herbicide neburon was prepared in 64% yield under our standard conditions.
