330150-98-6

Upstream product

• 330150-97-5 (S)-methyl 4-((tert-butyldiphenylsilyl)oxy)-3-methoxybutanoate 
• 124655-05-6 (S)-methyl 4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate 

Downstream Products

• 330150-89-5 (S)-4-((tert-butyldiphenylsilyl)oxy)-3-methoxybutanal 
• 330151-05-8 tert-Butyl-((2S,4S,5R)-2,4-dimethoxy-5-methyl-hept-6-enyloxy)-diphenyl-silane 
• 330151-01-4 tert-Butyl-((2S,4S,5S)-2,4-dimethoxy-5-methyl-hept-6-enyloxy)-diphenyl-silane 
• 330150-99-7 tert-Butyl-((2S,4R,5R)-2,4-dimethoxy-5-methyl-hept-6-enyloxy)-diphenyl-silane 
• 330151-03-6 tert-Butyl-((2S,4R,5S)-2,4-dimethoxy-5-methyl-hept-6-enyloxy)-diphenyl-silane 
• 330150-93-1 (3R,4S,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-3-methyl-hept-1-en-4-ol 
• 330150-91-9 (2S,4S,5S)-1-O-(tert-butyldiphenylsilyl)-5-methyl-2-O-methyl-6-hepten-1,2,4-triol 
• 330150-90-8 (2S,4R,5R)-1-O-(tert-butyldiphenylsilyl)-5-methyl-2-O-methyl-6-hepten-1,2,4-triol 
• 330150-92-0 (3S,4R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-3-methyl-hept-1-en-4-ol 
• 330151-06-9 (2R,3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-3,5-dimethoxy-2-methyl-hexan-1-ol 
• 330151-02-5 (2S,3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-3,5-dimethoxy-2-methyl-hexan-1-ol 
• 330151-00-3 (2R,3R,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-3,5-dimethoxy-2-methyl-hexan-1-ol 
• 330151-04-7 (2S,3R,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-3,5-dimethoxy-2-methyl-hexan-1-ol 

Relevant academic research and scientific papers

Stereochemical studies on sphinxolide: Advances in the J-based NMR determination of the relative configuration of flexible systems

An improved version of the J-based NMR configurational analysis of flexible organic molecules, that relies on extensive use of HSQC-TOCSY spectra, was applied to the stereochemical study of sphinxolide, a potent anti-tumor marine macrolide acting on cell microfilaments that has lately proven to circumvent multi-drug-resistance (MDR) in cancer cells. NMR data allowed stereochemical assignment of all molecular segments except the C18-C19 unit, whose configuration had to be addressed by a chemical/degradative approach.