330150-89-5

Upstream product

• 330150-97-5 (S)-methyl 4-((tert-butyldiphenylsilyl)oxy)-3-methoxybutanoate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 330150-98-6 4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-butan-1-ol 
• 124655-05-6 (S)-methyl 4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate 

Downstream Products

• 330150-91-9 (2S,4S,5S)-1-O-(tert-butyldiphenylsilyl)-5-methyl-2-O-methyl-6-hepten-1,2,4-triol 
• 330150-90-8 (2S,4R,5R)-1-O-(tert-butyldiphenylsilyl)-5-methyl-2-O-methyl-6-hepten-1,2,4-triol 
• 330150-92-0 (3S,4R,6S)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-3-methyl-hept-1-en-4-ol 
• 1264175-87-2 (5S,6R,8R,9S,11S)-3,3-diethyl-9-hydroxy-6,11-dimethoxy-5-((E)-6-methoxyhex-2-en-2-yl)-8,15,15-trimethyl-14,14-diphenyl-4,13-dioxa-3,14-disilahexadecan-7-one 
• 1264175-88-3 (2S,4S,5R,7R,8S,E)-1-((tert-butyldiphenylsilyl)oxy)-4,8-dihydroxy-2,7,13-trimethoxy-5,9-dimethyltridec-9-en-6-one 
• 1264175-89-4 C₃₄H₅₂O₆⁽¹⁸⁾OSi 
• 1264175-90-7 C₃₄H₅₂O₇⁽¹⁸⁾OSi 
• 330151-04-7 (2S,3R,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-3,5-dimethoxy-2-methyl-hexan-1-ol 
• 330151-00-3 (2R,3R,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-3,5-dimethoxy-2-methyl-hexan-1-ol 
• 330151-02-5 (2S,3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-3,5-dimethoxy-2-methyl-hexan-1-ol 
• 330151-06-9 (2R,3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-3,5-dimethoxy-2-methyl-hexan-1-ol 
• 330151-03-6 tert-Butyl-((2S,4R,5S)-2,4-dimethoxy-5-methyl-hept-6-enyloxy)-diphenyl-silane 
• 330150-99-7 tert-Butyl-((2S,4R,5R)-2,4-dimethoxy-5-methyl-hept-6-enyloxy)-diphenyl-silane 
• 330151-01-4 tert-Butyl-((2S,4S,5S)-2,4-dimethoxy-5-methyl-hept-6-enyloxy)-diphenyl-silane 

Relevant academic research and scientific papers

18O assisted analysis of a γ,δ-epoxyketone cyclization: Synthesis of the C16-C28 fragment of ammocidin D

The C16-C28 fragment common to the cytotoxic macrolide ammocidin D has been prepared by a stereospecific 5-exo closure of a γ,δ-epoxyketone followed by a rearrangement to a pyran acetal. The reaction pathway was traced by 18O labeling of the ke

Stereochemistry of sphinxolides and reidispongiolides. Asymmetric synthesis of the C17-C22 fragment of reidispongiolide A

Five fragments, 2a-4b, embedding all the stereogenic centers of reidispongiolide A (1), have been prepared by a controlled ozonolysis of the natural compound. The absolute stereochemistry of the asymmetric centers of fragment 3, corresponding to the C17-C22 portion of reidispongiolide A, was determined by enantioselective synthesis and application of the advanced Mosher method.

Stereochemical studies on sphinxolide: Advances in the J-based NMR determination of the relative configuration of flexible systems

An improved version of the J-based NMR configurational analysis of flexible organic molecules, that relies on extensive use of HSQC-TOCSY spectra, was applied to the stereochemical study of sphinxolide, a potent anti-tumor marine macrolide acting on cell microfilaments that has lately proven to circumvent multi-drug-resistance (MDR) in cancer cells. NMR data allowed stereochemical assignment of all molecular segments except the C18-C19 unit, whose configuration had to be addressed by a chemical/degradative approach.