330196-59-3Relevant academic research and scientific papers
Synthesis of some novel 2-azetidinones/4-thiazolidinones bearing 1, 3, 4-thiadiazole nucleus and screening for its anti-imflammatory activity
Gowramma,Praveen,Kalirajan,Babu
, p. 676 - 683 (2016/10/11)
Objective: The objective of the study was to synthesize a series of 3-chloro-4-(substituted phenyl)-1-(5-styryl-1, 3, 4-thiladiazole-2-yl) azetidin-2-one / 2-(substituted phenyl)-3-(5-styryl-1, 3, 4-thiadiazole-2-yl)-thiazolidin-4-one and screened for the
Synthesis, docking and biological evaluation of some novel 5-bromo-2-(5-aryl-1,3,4-thiadiazol-2-yl)isoindoline-1,3-dione derivatives targeting ATP-binding site of topoisomerase II
Gupta, Ankur,Singh, Priya,Kamble, Bhagyashree,Kulkarni, Aditi,Chandrasekar, Moola Joghee Nanjan
experimental part, p. 668 - 675 (2012/09/22)
Human Topoisomerase IIα (htopoIIα) is an approved and validated target for designing anticancer agents. Among the various methods to block the functions of htopoIIα, targeting ATP site for its competitive inhibition has been relatively less investigated.
