33021-67-9

Usage

Uses

Used in Agricultural Applications:
1-(2-chloroethyl)-3-(2,4,6-trimethylphenyl)urea is used as a herbicide for controlling unwanted vegetation in agricultural settings. It is effective in inhibiting plant growth by disrupting photosynthesis and other essential metabolic processes, thereby maintaining the productivity and quality of crops.
Used in Industrial Applications:
In industrial settings, 1-(2-chloroethyl)-3-(2,4,6-trimethylphenyl)urea is utilized as a herbicide to manage unwanted plant growth around infrastructure and facilities. Its application helps to prevent potential hazards and maintenance issues caused by overgrown vegetation.
It is crucial to note that due to the potential toxicity and environmental impact of 1-(2-chloroethyl)-3-(2,4,6-trimethylphenyl)urea, its use is strictly regulated in many countries. Proper handling, adherence to safety guidelines, and compliance with regulations are essential to minimize risks and ensure the responsible use of this chemical compound.

Upstream product

• 1943-83-5 2-chloroethyl isothiocyanate 
• 88-05-1 2,4,6-trimethylaniline 

Downstream Products

• 33022-06-9 N-(2-chloroethyl)-N-nitroso-N'-(2,4,6-trimethylphenyl)-urea 

Relevant academic research and scientific papers

METAL-LIGAND COMPLEX, OLEFIN POLYMERIZATION CATALYST DERIVED THEREFROM, AND OLEFIN POLYMERIZATION METHOD UTILIZING THE CATALYST

A metal-ligand complex has formula (I): wherein J, L, M, R1, R2, R3, R4, X, p, q, and r are defined herein. The metal-ligand complex is useful as a catalyst or catalyst precursor for olefin polymerization.

Antimitotic antitumor agents: Synthesis, structure-activity relationships, and biological characterization of N-aryl-N′-(2-chloroethyl)ureas as new selective alkylating agents

A series of N-aryl-N′-(2-chloroethyl)ureas (CEUs) and derivatives were synthesized and evaluated for antiproliferative activity against a wide panel of tumor cell lines. Systematic structure-activity relationship (SAR) studies indicated that: (i) a branched alkyl chain or a halogen at the 4-position of the phenyl ring or a fluorenyl/indanyl group, (ii) an exocyclic urea function, and (iii) a N′-2-chloroethyl moiety were required to ensure significant cytotoxicity. Biological experiments, such as immunofluorescence microscopy, confirmed that these promising compounds alter the cytoskeleton by inducing microtubule depolymerization via selective alkylation of β-tubulin. Subsequent evaluations demonstrated that potent CEUs were weak alkylators, were non-DNA-damaging agents, and did not interact with the thiol function of either glutathione or glutathione reductase. Therefore, CEUs are part of a new class of antimitotic agents. Finally, among the series of CEUs evaluated, compounds 12, 15, 16, and 27 were selected for further in vivo trials.

Synthesis and cytotoxic activity of new alkyl[3-(2-chloroethyl)ureido]benzene derivatives

Several alkyl[3-(2-chloroethyl)ureido] (CEU) benzene derivatives were prepared as potential anticancer agents. These new compounds were readily prepared in good yields by addition of anilines to 2-chloroethylisocyanate. Their cytotoxic activity was evaluated on human breast cancer (MDA-MB-231), human colon adenocarcinoma (LoVo) and mouse lymphocytic leukemia (P388D1) tumor cell lines. Several new CEUs were significantly more cytotoxic than the nitrogen mustard chlorambucil. The biological activity of these aromatic urea derivatives seems to be related to the nature and position of the alkyl substituents on the aromatic ring. Substitution by branched alkyl groups on position 4 of the aromatic ring led to cytotoxic molecules which are up to 5 times more potent than the standard chlorambucil.