33026-27-6

Basic information

• Product Name: ethyl 4,4-dimethyl-5-oxo-5-phenylpentanoate
• Synonyms: ethyl 4,4-dimethyl-5-oxo-5-phenylpentanoate
• CAS NO: 33026-27-6
• Molecular Weight: 248.322
• Mol File: 33026-27-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 4,4-dimethyl-5-oxo-5-phenylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4,4-dimethyl-5-oxo-5-phenylpentanoate(33026-27-6)
• EPA Substance Registry System: ethyl 4,4-dimethyl-5-oxo-5-phenylpentanoate(33026-27-6)

Safety Data

• Hazardous Substances Data: 33026-27-6(Hazardous Substances Data)

Upstream product

• 6414-69-3 ethyl 3-iodopropanoate 
• 611-70-1 phenyl isopropyl ketone 
• 539-74-2 Ethyl 3-bromopropionate 
• 87362-59-2 ethyl c-2-hydroxy-3,3-dimethyl-2-phenyl-r-1-cyclobutanecarboxylate 
• 87362-59-2 ethyl t-2-hydroxy-3,3-dimethyl-2-phenyl-r-1-cyclobutanecarboxylate 
• 6134-72-1 2-benzoyl-4-methylpentanoic acid ethyl ester 

Downstream Products

• 20215-66-1 5,5-dimethyl-6-phenyloxan-2-one 
• 87362-59-2 ethyl t-2-hydroxy-3,3-dimethyl-2-phenyl-r-1-cyclobutanecarboxylate 
• 611-70-1 phenyl isopropyl ketone 
• 2938-68-3 4,4-dimethyl-5-oxo-5-phenylpentanoic acid 

Relevant articles and documents

Efficient Transfer of Chelating Amides into Different Types of Esters and Lactones

We describe a general and versatile approach for the conversion of carboxylic acid amides into their corresponding esters despite the fact that the former are thermodynamically more stable. The transformations are mediated by the coordination of CuI by a chelating entity. The resulting weakening of the amide bond allows for nucleophilic attack by alcoholic hydroxyl functions. The principle is demonstrated for a wide variety of transformations, leading to different kinds of esters and lactones. Due to their high resonance energy, amides are generally very stable towards solvolysis. However, bispicolylamides can be activated for alcoholysis by an unusual metal coordination involving the electron pair of the amide nitrogen. Herein, we widened the scope of the reaction by transforming the amides into a range of esters and lactones.

THE NORRISH TYPE II PHOTOREACTION OF BENZOYLVALERATES. STEREOCHEMICAL CONTROL IN 1,4-BIRADICAL CYCLIZATION

The δ- and β-oxoester 1 and 5 underwent the Type II photoreaction to give the stereoisomeric cyclobutanol 2 and 6, respectively; the ethoxycarbonyl group in the esters determines the stereochemistry of 1,4-biradical cyclization.