6414-69-3Relevant articles and documents
Baker
, p. 216 (1933)
Enantioselective allylic hydroxylation of w-alkenoic acids and esters by P450 BM3 monooxygenase
Neufeld, Katharina,Henssen, Birgit,Pietruszka, J?rg
supporting information, p. 13253 - 13257 (2015/02/19)
Chiral allylic alcohols of w-alkenoic acids and derivatives thereof are highly important building blocks for the synthesis of biologically active compounds. The direct enantioselective C-H oxidation of linear terminal olefins offers the shortest route toward these compounds, but known synthetic methods are limited and suffer from low selectivities. Described herein is an enzymatic approach using the P450 BM3 monooxygenase mutant A74G/L188Q, which catalyzes allylic hydroxylation with high to excellent chemo- and enantioselectivities providing the desirable secondary alcohols.
PDE 10a Inhibitors for the Treatment of Type II Diabetes
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Paragraph 0865; 0866, (2015/01/06)
Disclosed are compounds, compositions and methods for treating Type II diabetes. Such compounds are represented by Formula (I) as follows: wherein R1, R2, L, and Q are defined herein.
METHOD FOR INCREASING SPECIFIC SURFACE AREA OF SLIGHTLY SOLUBLE DRUG
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Page/Page column 7, (2010/11/25)
The preparation method of the powder of which dissolution rate improves is characterized by including of the process that slightly soluble drug having acidic group (e.g., 3-(5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-3,4-dihydronaphthalen-1
