33026-82-3Relevant academic research and scientific papers
Reactive intermediates in the H-phosphonate synthesis of oligonucleotides
Powles, Nicholas,Atherton, John,Page, Michael I.
, p. 5940 - 5947 (2012)
The formation of H-phosphonate diesters is an important step in the synthesis of oligonucleotides. Using diphenylchlorophosphate as the activator for the coupling step is often accompanied by side reactions as a result of self 'capping' and other reactions of the reactive intermediate. In the absence of base, the activation of ethyl H-phosphonate with diphenylchlorophosphate probably occurs through the intermediate formation of bis diethyl pyro-di-H-phosphonate rather than the expected diphenyl ethyl pyro-H-phosphonate. Pyridine acts as a nucleophilic catalyst converting diphenylchlorophosphate to its pyridinium adduct. Several side and unwanted reactions are quantified so that conditions to minimise these can be identified.
3-Phosphono-2-(N-cyanoimino)thiazolidine derivatives, new phosphorylating agents for alcohols
Maezaki, Naoyoshi,Furusawa, Akemi,Hirose, Yuki,Uchida, Shuji,Tanaka, Tetsuaki
, p. 3493 - 3498 (2007/10/03)
We have developed new phosphorylating agents, 3-phosphono-2-(N-cyanoimino)-thiazolidine derivatives (3-phosphono-NCTs), which were readily synthesized by phosphorylation of NCT, and transformed primary and secondary alcohols into phosphates in good yield. The transfer of three kinds of dialkylphosphono groups [(PhO)2P(O)-, (EtO)2P(O)-, (Cl3CCH2O)2P(O)-] proceeded in excellent yields. Selective phosphorylation of various alcohols was also accomplished.
NOUVEAUX TRIOXOPHOSPHETANES GENERATEURS D'OXYGENE SINGULET A BASSE TEMPERATURE
Khatib, Fayez El,Tachon, Christine,Caminade, Anne-Marie,Koenig, Max
, p. 3007 - 3010 (2007/10/02)
We have prepared phosphite ozonides 1b-3b which are efficient and clean singlet oxygene generators at low temperature.
