330436-78-7Relevant articles and documents
Synthesis of internal alkynes through the Pd-catalyzed coupling of heteroaryl halides with terminal alkynes
Lu, Linhua,Yan, Hong,Sun, Peng,Zhu, Yan,Yang, Hailong,Liu, Defu,Rong, Guangwei,Mao, Jincheng
supporting information, p. 1644 - 1648 (2013/04/10)
Sonogashira-type cross-couplings of functionalized heterocyclic halides with terminal alkynes were performed efficiently at room temperature. The heteroaryl halides were easily prepared from the corresponding heterocyclic compounds. The catalytic system tolerated a very broad scope of substrates; oxazoles, thiazoles, and furans participate in this type of reaction for the first time. This reaction provides an efficient method for the direct functionalization of heterocycles. Sonogashira-type cross-coupling of functionalized heterocyclic halides with terminal alkynes are performed efficiently at room temperature. The catalytic system tolerates a very broad scope of substrates; oxazoles, thiazoles, and furans participate in this type of reaction for the first time. The reaction provides an efficient method for the direct functionalization of heterocycles. Copyright
Remarkable synthesis of 2-(Z)-6-(E)-4H- [1,4]-thiazepin-5-ones by zwitterionic rhodium-catalyzed chemo- and regioselective cyclohydrocarbonylative ring expansion of acetylenic thiazoles
Van den Hoven,Alper
, p. 1017 - 1022 (2007/10/03)
Cyclohydrocarbonylative ring expansion of acetylenic thiazoles in the presence of CO, H2, and catalytic quantities of the zwitterionic rhodium complex η6-C6H5BPh3) -Rh+(1,5-COD) and triphenyl phosphite affords thiazepinones in 61 to 90% yields. This novel transformation of a 5- to a 7-membered heterocycle is readily applied to acetylenic thiazoles containing hydro, alkyl, alkyl halide, vinyl, and benzo substitutents in positions 4 and 5 of the thiazole ring in addition to alkyl-, ether-, ester-, vinyl-, and aryl-substituted alkynes at position 2.
