330442-80-3

Upstream product

• 154243-34-2 methyl 3-hydroxy-2-methylene-3-(2-chlorophenyl)propanoate 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 1010833-02-9 methyl (Z)-3-(2-chlorophenyl)-2-(thiocyanomethyl)propenoate 
• 1255193-98-6 methyl (Z)-3-(2-chlorophenyl)-2-(isothioureidomethyl)-2-propenoate hydrobromide 
• 1335284-72-4 C₁₉H₁₆ClNO₂ 
• 1367876-26-3 [(Z)-3-(2-chlorophenyl)-2-methoxycarbonyl-2-propenyl]triphenylphosphonium bromide 
• 1614-98-8 3-(2-chlorophenyl)-2-methylacrylic acid 
• 364633-50-1 3-(2-chlorophenyl)-2-methylacrylic acid methyl ester 
• 1589493-43-5 methyl (2E)-2-{[N-(2-formylphenyl)(4-methylbenzene)sulfonamido]methyl}-3-(2-chlorophenyl)prop-2-enoate 

Relevant academic research and scientific papers

Design, synthesis and evaluation of 3-arylidene azetidin-2-ones as potential antifungal agents against Alternaria solani Sorauer

A new concise and facile method was explored to synthesize a collection of new 3-arylidene azetidin-2-ones, which could be regarded as the derivatives of the hybrid scaffold of bioactive natural cinnamamide and heterocycle azetidi-2-one. The structures of

Allylic isothiouronium salts: The discovery of a novel class of thiourea analogues with antitumor activity

A series of 28 aryl- and alkyl-substituted isothiouronium salts were readily synthesized in high yields through the reaction of allylic bromides with thiourea, N-monosubstituted thioureas or thiosemicarbazide. The S-allylic isothiouronium salts substitute

Multicomponent cascade assembly for quinolinopyranpyrazole architectures

A highly efficient, multicomponent protocol for the construction of functionalized quinolinopyranpyrazole scaffolds with high stereoselectivity has been developed through the application of a domino reaction. All the quinolinopyranpyrazoles were synthesiz

Multicomponent Cascade Assembly for Quinolinopyranpyrazole Architectures

A highly efficient, multicomponent protocol for the construction of functionalized quinolinopyranpyrazole scaffolds with high stereoselectivity has been developed through the application of a domino reaction. All the quinolinopyranpyrazoles were synthesiz

Synthesis of 1,3-thiazine-2,4-diones with potential anticancer activity

2-Amino-1,3-thiazin-4-ones were subjected to acetylation followed by mild acid hydrolysis to give compounds containing the 1,3-thiazine-2,4-dione core. The potential of these S,N-containing heterocycles as antitumor agents against human cancer cell lines,

Microwave-assisted synthesis of the (E)-α-methylalkenoate framework from multifunctionalized allylic phosphonium salts

A convenient and general microwave-assisted method for the synthesis of stereochemically defined α-methylalkenoic acids and esters from allylic phosphonium salts in a basic aqueous medium is described. A selective preparation of acids or esters was dependent on the base (NaOH or NaHCO 3) employed in the reaction and could be achieved with good to excellent yields under mild conditions in the absence of hydrides and reducing agents.

Exploring the reaction of multifunctional allylic bromides with N,S-dinucleophiles: Isothiuronium salts and analogs as useful motifs to assemble the 1,3-thiazine core

The reactivity profile of allylic bromides (derived from the Morita-Baylis-Hillman reaction) towards thiourea derivatives and further transformations of the resulting isothiuronium bromides are described. Isothiuronium salts, prepared in near quantitative

A new route to allyl thiols and allyl thiocarbamates from Baylis-Hillman adducts

A facile synthesis of trisubstituted allyl thiols and allyl thiocarbamates has been accomplished from Baylis-Hillman adducts through bromination, thiocyanation, and acid-assisted hydrolysis reaction.

A rapid and efficient stereoselective synthesis of (Z)- and (E)-allyl bromides from Baylis-Hillman adducts using bromo(dimethyl)sulfonium bromide

Treatment of Baylis-Hillman adducts 1 with bromo(dimethyl)sulfonium bromide, Br(Me2)S+Br-, in MeCN was found to stereoselectively afford (Z)- and (E)-allyl bromides 2. The reaction is rapid at room temperature, high-yieldi

Fast and efficient preparation of Baylis-Hillman-derived (E)-allylic azides and related compounds in aqueous medium

A practical access to alkyl- and aryl-substituted (E)-2-(azidomethyl)alkenoates and related azido compounds from the corresponding allylic bromides in aqueous acetone is described. An alternative method to obtain the starting bromides based on heterogeneo