1614-98-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Propenoic acid, 3-(2-chlorophenyl)-2-methylis used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Pesticide Industry:
In the pesticide industry, 2-Propenoic acid, 3-(2-chlorophenyl)-2-methylis used as a key component in the formulation of various pesticides, leveraging its chemical structure to enhance the effectiveness of these products.
Used in Chemical Synthesis:
2-Propenoic acid, 3-(2-chlorophenyl)-2-methylis used as a building block in the synthesis of a range of organic compounds, contributing to the creation of new chemical entities with diverse applications.
Used as a Reagent in Chemical Reactions:
2-Propenoic acid, 3-(2-chlorophenyl)-2-methylserves as a reagent in various chemical reactions, facilitating specific transformations and processes that are essential in the production of different chemical products.

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 123-62-6 propionic acid anhydride 
• 110-89-4 piperidine 
• 516-05-2 methyl-propanedioic acid 
• 364633-50-1 3-(2-chlorophenyl)-2-methylacrylic acid methyl ester 
• 133455-43-3 trans-ethyl-(2-chloro)-α-methylcinnamate 
• 330442-80-3 methyl (2Z)-2-(bromomethyl)-3-(2-chlorophenyl)prop-2-enoate 
• 154243-34-2 methyl 3-hydroxy-2-methylene-3-(2-chlorophenyl)propanoate 
• 1367876-26-3 [(Z)-3-(2-chlorophenyl)-2-methoxycarbonyl-2-propenyl]triphenylphosphonium bromide 

Downstream Products

• 336181-45-4 2-[2-(2-chloro-phenyl)-1-methyl-vinyl]-1H-benzoimidazole 
• 51220-02-1 (E)-3-(2-chlorophenyl)-2-methylacrylonitrile 
• 91445-90-8 3-(2-Chlor-phenyl)-2,3-dibrom-2-methyl-propionsaeure 

Relevant academic research and scientific papers

Highly efficient Rh-catalyzed asymmetric hydrogenation of α,β-unsaturated nitriles

A highly efficient enantioselective hydrogenation of α,β-unsaturated nitriles catalyzed by Rh-(R,R)-f-spiroPhos complex has been developed. With Rh-(R,R)-f-spiroPhos catalyst and under mild conditions, a wide range of α,β-unsaturated nitriles including the (E)- and (Z)-isomers of 3-alkyl-3-aryl, 3,3-diaryl, and 3,3-dialkyl α,β-unsaturated nitriles were hydrogenated to the corresponding chiral nitriles with excellent enantioselectivities (up to 99.9% ee) and high turnover numbers (TON up to 10,000).

Microwave-assisted synthesis of the (E)-α-methylalkenoate framework from multifunctionalized allylic phosphonium salts

A convenient and general microwave-assisted method for the synthesis of stereochemically defined α-methylalkenoic acids and esters from allylic phosphonium salts in a basic aqueous medium is described. A selective preparation of acids or esters was dependent on the base (NaOH or NaHCO 3) employed in the reaction and could be achieved with good to excellent yields under mild conditions in the absence of hydrides and reducing agents.

Synthetic applications of Baylis-Hillman chemistry: An efficient and solely stereoselective synthesis of (E)-α-methylcinnamic acids and potent hypolipidemic agent LK-903 from unmodified Baylis-Hillman adducts

An efficient and solely stereoselective synthesis of (E)-α- methylcinnamic acids has been accomplished in single pot by reduction of the unmodified Baylis-Hillman adducts, methyl-3-hydroxy-3-aryl-2- methylenepropanoates with I2/NaBH4 reagent system at room temperature followed by hydrolysis. The efficacy of this method has been proved in the total synthesis of 1-[p-(myristyloxy)-α-methylcinnamoyl]glycerol, LK-903, a highly active hypolipidemic agent.