33045-53-3

Basic information

• Product Name: Ethyl 2-methoxy-5-sulfamoylbenzoate
• Synonyms: Ethyl 2-methoxy-5-(sulfamoylmethyl)benzoate;2-METHOXYL-5-METHYLSULFONYLBENZOIC ACID METHYL ESTER;Ethyl 2-methoxy-5-sulfamoylbenzoate;Ethyl 5-sulphamoyl-o-anisate;Sulpiride IMpurity C;Sulpiride Impurity C(EP)
• CAS NO: 33045-53-3
• Molecular Formula: C₁₀H₁₃NO₅S
• Molecular Weight: 259.28
• EINECS: 251-359-7
• Product Categories: FINE Chemical & INTERMEDIATES
• Mol File: 33045-53-3.mol

Chemical Properties

• Melting Point: 148-151 °C
• Boiling Point: 446.5 °C at 760 mmHg
• Flash Point: 223.8 °C
• Appearance: /
• Density: 1.317 g/cm³
• Vapor Pressure: 3.63E-08mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: Refrigerator
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 9.95±0.60(Predicted)
• Water Solubility: 1.545g/L at 25℃
• CAS DataBase Reference: Ethyl 2-methoxy-5-sulfamoylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-methoxy-5-sulfamoylbenzoate(33045-53-3)
• EPA Substance Registry System: Ethyl 2-methoxy-5-sulfamoylbenzoate(33045-53-3)

Safety Data

• Hazardous Substances Data: 33045-53-3(Hazardous Substances Data)

Usage

Flammability and Explosibility

Notclassified

InChI:InChI=1/C10H13NO5S/c1-3-16-10(12)8-6-7(17(11,13)14)4-5-9(8)15-2/h4-6H,3H2,1-2H3,(H2,11,13,14)

Upstream product

• 64-17-5 ethanol 
• 33045-52-2 methyl 2-methoxy-5-sulfamoyl-benzoate 

Downstream Products

• 129010-92-0 2-Methoxy-N-(3-piperidin-1-yl-propyl)-5-sulfamoyl-benzamide 
• 129010-96-4 2-Methoxy-5-sulfamoyl-N-[3-(4-o-tolyl-piperazin-1-yl)-propyl]-benzamide 
• 129011-05-8 2-Methoxy-N-{3-[4-(3-methoxy-phenyl)-piperazin-1-yl]-propyl}-5-sulfamoyl-benzamide 
• 102535-20-6 N-(2-Dimethylamino-1-methyl-ethyl)-2-methoxy-5-sulfamoyl-benzamide 
• 68475-40-1 N-(1-cyclopropylmethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide 
• 15676-16-1 N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide 
• 103054-50-8 2-methoxy-5-sulfamoylbenzyl chloride 
• 129011-03-6 2-Methoxy-N-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-5-sulfamoyl-benzamide 
• 113681-63-3 N-benzyl-5-(aminosulfonyl)-2-methoxybenzamide 
• 129011-07-0 2-Methoxy-N-{3-[4-(4-methoxy-phenyl)-piperazin-1-yl]-propyl}-5-sulfamoyl-benzamide 
• 5607-65-8 2-Methoxy-5-sulfamoylbenzoesaeure-N-(2-diethylaminoethyl)-amid 
• 129010-98-6 2-Methoxy-5-sulfamoyl-N-[3-(4-p-tolyl-piperazin-1-yl)-propyl]-benzamide 
• 900165-91-5 3-(Hydroxymethyl)-4-methoxybenzenesulfonamide 
• 129010-99-7 N-{3-[4-(4-Ethyl-phenyl)-piperazin-1-yl]-propyl}-2-methoxy-5-sulfamoyl-benzamide 

Relevant articles and documents

POTENTIAL NEUROLEPTICS OF THE ORTHOPRAMIDE SERIES; SYNTHESIS OF N-SUBSTITUTED 5-(AMINOSULFONYL)-2-METHOXYBENZAMIDES

The mixed anhydride of 5-(aminosulfonyl)-2-methoxybenzoic acid (VII) and monoethyl carbonate reacted with benzylamine, 1-methylpiperazine, and 1-benzylpiperazine to give the 5-(aminosulfonyl)-2-methoxybenzamides II, IV, and V.Heating the ethyl ester X with 4-amino-1-methylpiperidine resulted in the amide III.Reaction of 5-(chlorosulfonyl)-2-methoxybenzoyl chloride (XI) with 1-benzylpiperazine afforded 5-(4-benzylpiperazinosulfonyl)-2-methoxybenzoic acid 4-benzylpiperazide (VI).Compounds II-VI are analogues of the antidopaminergic and antiemetic agent sulpiride (I) but only the benzylpiperazides V and VI showed indications of psychotropic activity of the neuroleptic type.