330469-35-7Relevant academic research and scientific papers
Model Systems for Flavoenzyme Activity: Relationships between Cofactor Structure, Binding and Redox Properties
Legrand, Yves-Marie,Gray, Mark,Cooke, Graeme,Rotello, Vincent M.
, p. 15789 - 15795 (2003)
A series of flavins were synthesized bearing electron-withdrawing and -donating substituents. The electrochemical properties of these flavins in a nonpolar solvent were determined. The recognition of these flavins by a diamidopyridine (DAP) receptor and the effect this receptor has on flavin redox potential was also quantified. It was found that the DAP-flavin binding affinity and the reduction potentials (E1/2) for both the DAP-bound and unbound flavins correlated well with functions derived from linear free energy relationships (LFERs). These results provide insight and predictive capability for the interplay of electronics and redox state-specific interactions for both abiotic and enzymatic systems.
