330596-38-8Relevant academic research and scientific papers
A new phenoxyacetate-based linker system for the solid-phase synthesis of oligosaccharides.
Wu,Grathwohl,Schmidt
, p. 747 - 750 (2007/10/03)
[structure: see text]. A novel linker system has been designed, and its first application to solid-phase oligosaccharide synthesis is described. The use of the highly reactive o-nitro-phenoxyacetate linker allows a fast and quantitative cleavage using mild basic conditions. This method combined with the trichloroacetimidate glycosylation exhibits highly promising results as demonstrated for the synthesis of tetrasaccharide 1 (n = 3) containing glucose beta(1 --> 4) and beta(1 --> 6) linkages.
