3306-60-3

Usage

Uses

Used in Pharmaceutical Industry:
(7S)-7-(acetylamino)-2,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-1-yl acetate is used as a potential pharmaceutical agent for its unique structural features. (7S)-7-(acetylamino)-2,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-1-yl acetate's acetylamino and methoxy groups may contribute to its interaction with biological targets, making it a candidate for the development of new drugs or therapies.
Used in Chemical Research:
In the field of chemical research, (7S)-7-(acetylamino)-2,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-1-yl acetate serves as a subject of study to understand its chemical properties, reactivity, and potential applications in various chemical processes. Its complex structure may offer insights into the development of new synthetic methods or the creation of novel chemical compounds.
Used in Material Science:
(7S)-7-(acetylamino)-2,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-1-yl acetate may be utilized in material science for the development of new materials with specific properties. (7S)-7-(acetylamino)-2,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-1-yl acetate's structural elements could be exploited to create materials with tailored characteristics for various applications, such as in electronics, coatings, or advanced materials.

Upstream product

• 64-86-8 colchicine 
• 75-36-5 acetyl chloride 

Downstream Products

• 3464-68-4 N-[(7S)-1-hydroxy-2,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide 

Relevant academic research and scientific papers

METHODS AND USES OF COLCHICINE DERIVATIVES

Colchicine derivative(s), method(s) and use(s) thereof for treatment of inflammation. In certain embodiments, the colchicine derivative is a compound of Formula I: (I)

NOVEL COLCHICINE DERIVATIVES, METHODS AND USES THEREOF

The invention relates to colchicine derivatives, methods and uses thereof for treatment of cancer. In certain embodiments, the colchicine derivative comprises a compound of formula (I), wherein Z is O or S; R1 is selected fro H, a halo group, a substituted or unsubstituted hydrocarbon group, or a substituted or unsubstituted heterogeneous group; R2 and R3 are each independently selected from H, a halo group, a substituted or unsubstituted hydrocarbon group, a substituted or unsubstituted heterogeneous group, a substituted or unsubstituted carbocyclic group, a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aromatic, or a substituted or unsubstituted heteroaromatic; R is selected from H or a substituted or unsubstituted hydrocarbon group, with the proviso that when R, R2 and R3 are methyl groups, R1 is not -COCH3.

The efficacy of new colchicine derivatives and viability of the T-Lymphoblastoid cells in three-dimensional culture using 19F MRI and HPLC-UV ex vivo

The paper describes ex vivo applications of colchicine derivatives for the treatment of human T-Lymphoblastoid (CEM) cells. Moreover, the role of the substitutions of ring A at C-1 and C-7 side chain of colchicine analogues was probed by the synthesis and examination of their effects on the three-dimensional (3-D) CEM cells' growth. The CEM cells were cultured in the hollow fiber bioreactor (HFB) device. We used 1H and 19F magnetic resonance imaging (MRI) to monitor changes in 3-D CEM cell culture. 19F MRI was used for visualization of the cellular uptake of new fluorine derivatives. Before and after treatment CEM cells profile was investigated with high performance liquid chromatography (HPLC-UV). Crown Copyright

Biosynthesis. Part 27.1,2 Colchicine: Studies of the phenolic oxidative coupling and ring-expansion processes based on incorporation of multiply labelled 1-phenethylisoquinolines

Earlier research from our group had proved that the biosynthesis of colchicine and its tropolonoid relatives involves the oxidative ring-closure of a 1-phenethyltetrahydroisoquinoline, autumnaline, followed by extensive modification of the cyclised product. These steps pose many mechanistic and stereochemical questions which are set out in the Introduction. The sequel then provides the answers based on the results from a series of incorporation experiments on Colchicum plants involving multiply labelled forms of autumnaline and its biological precursors. These multiply labelled samples required the synthesis of eleven differently labelled tetrahydroisoquinolines; the methods used to introduce the labels are described. Autumnaline is shown to be present in Colchicum autumnale plants and labelled forms of some precursors of it are synthesised and studied. Taken together, the findings allow further definition of a substantial part of the biosynthetic pathway to colchicine and its relatives.