33062-38-3Relevant academic research and scientific papers
Synthesis of 2-(4,6-Dimethoxy-1,3,5-triazin-2-yloxyimino) derivatives: Application in solution peptide synthesis
Al-Warhi, Tarfah I.,AL-Hazimi, Hassan M.A.,El-Faham, Ayman,Albericio, Fernando
experimental part, p. 9403 - 9417 (2011/03/22)
A new class of 1,3,5-triazinyloxyimino derivatives were prepared, characterized and tested for reactivity in solution peptide synthesis. The new triazinyloxyimino derivatives failed to activate the carboxyl group during formation of peptide bonds, but gav
Morpholine-based immonium and halogenoamidinium salts as coupling reagents in peptide synthesis
El-Faham, Ayman,Albericio, Fernando
, p. 2731 - 2737 (2008/09/19)
(Chemical Equation Presented) Here we describe a new family of N-form immonium-type coupling reagents that differ in their carbocation skeleton structure. The N-methylpiperazine derivative failed to form immonium salts, while the thiomorpholine derivative did not give better results than the coupling reagents currently used. The presence of the morpholine had a marked influence on the solubility and stability as well as the reactivity of the reagent. Finally, the fluoroamidinium salt performed extremely well in the presence of only 1 equiv of base, thereby confirming the effect of the proton acceptor in the reaction.
A One-Pot Peptide Synthesis via Se-phenyl Carboselenoate in Mixed Aqueous/Organic Solvent System
Ghosh, Sunil Kumar,Singh, Usha,Chandha, Mohindra S.,Mamdapur, Vasant R.
, p. 1566 - 1568 (2007/10/02)
A one pot synthesis of peptides with free C-terminal residues has been accomplished via the active Se-phenyl carboselenoate using diphenyl diselenide, tributylphosphine, and N-methylmorpholine N-oxide in an acetonitrile- water mixed solvent system.Free amino acids and peptides have been used as the amine component without pH adjustment.
Additives Based on Liquid Crystal Forming Structure Elements for Suppressing Racemization in Peptide Synthesis by the DCC- and Mixed Anhydrides Methods
Jeschkeit, H.,Strube, M.,Przybylski, J.,Miecznikowska, H.,Kupryszewski, G.
, p. 638 - 646 (2007/10/02)
A new type of additives suppressing racemization during peptide synthesis by the DCC- and mixed anhydrides methods are liquid crystal forming organic molecules or similar compounds with a specific long chain structure.The suppressing effect of the new additives was followed by the Anderson test, the modifid Young and n.m.r. tests.There was no racemization in a new Leu-enkephalin synthesis by the mixed anhydrides method with azoxybenzene as additive.
INFLUENCE OF ADDITIVES ON SUPPRESSION OF RACEMIZATION IN PEPTIDE SYNTHESIS. PART IV. THE USE OF ADDITIVES FOR SUPPRESSION OF RACEMIZATION IN PEPTIDE SYNTHESIS BY THE METHOD OF MIXED ANHYDRIDES
Przybylski, Jozef,Sokolowska, Barbara
, p. 455 - 468 (2007/10/02)
The changes of employing antiracemization additives in peptide synthesis by the method of mixed anhydrides were investigated by the Anderson and NMR tests.
