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1-Piperidinecarbodithioic acid, 2-nitro-1-phenylethyl ester is a functionalized dithiocarbamate derivative synthesized through a one-pot three-component reaction involving piperidine, carbon disulfide, and β-nitrostyrene under mild conditions. 1-Piperidinecarbodithioic acid, 2-nitro-1-phenylethyl ester exhibits notable antimicrobial properties, demonstrating comparable or superior antibacterial and antifungal activities against certain Gram-positive and Gram-negative bacteria, as well as fungi, when compared to standard reference drugs like ampicillin, streptomycin, and amphotericin B. The efficient synthesis method and promising pharmacological profile highlight its potential as an antimicrobial agent. Other names for 1-Piperidinecarbodithioic acid, 2-nitro-1-phenylethyl ester may include: - 2-Nitro-1-phenylethyl piperidine-1-carbodithioate - Piperidine-1-carbodithioic acid 2-nitro-1-phenylethyl ester - (2-Nitro-1-phenylethyl) piperidine-1-dithiocarbamate

33064-58-3

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33064-58-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 33064-58-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,0,6 and 4 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 33064-58:
(7*3)+(6*3)+(5*0)+(4*6)+(3*4)+(2*5)+(1*8)=93
93 % 10 = 3
So 33064-58-3 is a valid CAS Registry Number.

33064-58-3Downstream Products

33064-58-3Relevant academic research and scientific papers

Conjugated addition reaction of amine, carbon disulfide to electrophilic alkenes in the presence of anhydrous potassium phosphate

Guo,Ge,Cheng,Li

, p. 3021 - 3025 (2001)

Different kinds of β-electron-withdraw group substituted ethyl dithiocarbamates (3) were prepared by the conjugated addition of an amine (1) and carbon disulfide to electrophilic alkenes (2) in the presence of anhydrous potassium phosphate under mild condition in good yields.

Efficient synthesis of functionalized dithiocarbamate derivatives through one-pot three-component reaction and evaluation of their antimicrobial activities

Ghabraie, Elmira,Moghimi, Hamid,Balalaie, Saeed,Bararjanian, Morteza,Rominger, Frank,Bijanzadeh, Hamid Reza

, p. 725 - 732 (2013)

The one-pot three-component reaction of primary and secondary amines, carbon disulfide and β-nitrostyrene derivatives in neat condition at room temperature afforded functionalized dithiocarbamate derivatives in good to high yields. High bond-forming efficiency and easy work-up are advantages of this reaction. In vitro antimicrobial activities of synthesized compounds were studied against four Gram-positive bacteria, four Gram-negative bacteria and four fungi. The screening for the antimicrobial activity was performed by twofold serial dilution technique. Notably, some synthesized compounds displayed comparable or even better antibacterial and antifungal activities against some tested strains than the reference drugs ampicillin, streptomycin and amphotericin B, respectively. Graphical abstract: A series of novel dithiocarbamates 4a-j have been synthesized via three-component reaction and compared pharmacologically concerning their antimicrobial and antibacterial activities as well as antifungal activity [Figure not available: see fulltext.].

An expedient, fast and competent synthesis of organic dithiocarbamates over nanocrystalline MgO in water at room temperature

Karmakar, Bikash,Banerji, Julie

experimental part, p. 6584 - 6586 (2011/12/22)

A new, expeditious, efficient and eco-friendly method for the synthesis of organic dithiocarbamates has been achieved at room temperature using basic nanocrystalline MgO catalyst in aqueous condition. The method has been applied for the synthesis of a range of compounds with variable functionalities in excellent yield and selectivity.

Dithiocarbamate ester bactericides and fungicides

-

, (2008/06/13)

The present invention relates to certain novel dithiocarbamate esters, methods for their synthesis and their use as bactericidal and fungicidal agents.

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