330641-50-4

Basic information

• Product Name: C₇₁H₁₁₃N₉O₁₃S₃
• Synonyms: C₇₁H₁₁₃N₉O₁₃S₃
• CAS NO: 330641-50-4
• Molecular Weight: 1396.93
• Mol File: 330641-50-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₇₁H₁₁₃N₉O₁₃S₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₇₁H₁₁₃N₉O₁₃S₃(330641-50-4)
• EPA Substance Registry System: C₇₁H₁₁₃N₉O₁₃S₃(330641-50-4)

Safety Data

• Hazardous Substances Data: 330641-50-4(Hazardous Substances Data)

Upstream product

• 330641-30-0 2-methylamino-benzoic acid 8-(2-{[1-(2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanyl-butyrylamino]-acetylamino}-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-amino}-2-methoxycarbonyl-ethylsulfanyl)-2,6-dimethyl-octa-2,6-dienyl ester 
• 330641-28-6 N-(9-fluorenylmethyloxycarbonyl)-L-methionylglycyl-L-leucyl-L-proline allyl ester 
• 330641-42-4 N-(6-maleimidocaproyl)-glycyl-S-hexadecyl-L-cysteine tert-butyl ester 
• 330641-29-7 N-(9-fluorenylmethyloxycarbonyl)-L-methionylglycyl-L-leucyl-L-proline 
• 262596-78-1 bis-(N-allyloxycarbonylglycyl)-L-cystine bis-(tert-butyl ester) 
• 262596-79-2 N-allyloxycarbonylglycyl-S-hexadecyl-L-cysteine tert-butyl ester 
• 330641-40-2 2-(2-amino-acetylamino)-3-hexadecylsulfanyl-propionic acid tert-butyl ester 
• 330641-24-2 N-(9-fluorenylmethyloxycarbonyl)-L-methionylglycine allyl ester 
• 330641-22-0 2-Methylamino-benzoic acid (2E,6E)-8-((R)-2-amino-2-methoxycarbonyl-ethylsulfanyl)-2,6-dimethyl-octa-2,6-dienyl ester 
• 223125-35-7 2-Methylamino-benzoic acid (2E,6E)-2,6-dimethyl-8-(tetrahydro-pyran-2-yloxy)-octa-2,6-dienyl ester 
• 223125-39-1 2-Methylamino-benzoic acid (2E,6E)-8-hydroxy-2,6-dimethyl-octa-2,6-dienyl ester 
• 330641-20-8 (E,E)-8-O-(2-N-methyl-aminobenzoyl)-3,7-dimethyl-2,6-octadiene-1-chloride 
• 112-82-3 hexadecanyl bromide 
• 77275-43-5 N-(9-fluorenylmethyloxycarbonyl)-L-methionylglycine 

Relevant articles and documents

Synthesis of functional ras lipoproteins and fluorescent derivatives

For the study of biological signal transduction, access to correctly lipidated proteins is of utmost importance. Furthermore, access to bioconjugates that embody the correct structure of the protein but that may additionally carry different lipid groups or labels (i.e., fluorescent tags) by which the protein can be traced in biological systems, could provide invaluable reagents. We report here of the development of techniques for the synthesis of a series of modified Ras proteins. These modified Ras proteins carry a number of different, natural and non-natural lipid residues, and the process was extended to also provide access to a number of fluorescently labeled derivatives. The maleimide group provided the key to link chemically synthesized lipopeptide molecules in a specific and efficient manner to a truncated form of the H-Ras protein. Furthermore, a preliminary study on the biological activity of the natural Ras protein derivative (containing the normal farnesyl and palmitoyl lipid residues) has shown full biological activity. This result highlights the usefulness of these compounds as invaluable tools for the study of Ras signal transduction processes and the plasma membrane localization of the Ras proteins.