330657-31-3Relevant academic research and scientific papers
Synthesis of bioactive polyheterocyclic ring systems as 5α-reductase inhibitors
Abdel Hafez, Naglaa A.,Farghaly, Thoraya A.,Al-Omar, Mohamed A.,Abdalla, Mohamed M.
, p. 4838 - 4844 (2010)
Simple synthetic strategies for the hitherto unreported [1,2,4]triazolo[4,3-a]pyrido[4,3-d]pyrimidines 8 and [1,2,4]triazolo[4′, 3′:1,2]pyrimido[4,5-b][1,6]naphthyridine-5-one 15 are described based on reaction of thione 3 and 12 with hydrazonoyl chloride 1a-h, respectively. The structures of products 8 and 15 were confirmed by spectroscopic and X-ray crystallographic analyses. Also, the mechanism of such reactions was discussed. In addition, reaction of compound 12 with bromoacetic acid and hydrazine hydrate was investigated. Compounds were screened against 5α-reductase and showed activities with good LD50 and LD90 for all compounds.
CURCUMIN ANALOGS AND METHODS OF MAKING AND USING THEREOF
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Page/Page column 65; 74, (2014/02/16)
Compounds having Formula I or II, and methods of making and using thereof, are described herein:
