330667-10-2Relevant academic research and scientific papers
Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent
Hadimani, Mallinath B.,MacDonough, Matthew T.,Ghatak, Anjan,Strecker, Tracy E.,Lopez, Ramona,Sriram, Madhavi,Nguyen, Benson L.,Hall, John J.,Kessler, Raymond J.,Shirali, Anupama R.,Liu, Li,Garner, Charles M.,Pettit, George R.,Hamel, Ernest,Chaplin, David J.,Mason, Ralph P.,Trawick, Mary Lynn,Pinney, Kevin G.
, p. 1668 - 1678 (2013)
The natural products colchicine and combretastatin A-4 are potent inhibitors of tubulin assembly, and they have inspired the design and synthesis of a large number of small-molecule, potential anticancer agents. The indole-based molecular scaffold is prom
