330666-86-9

Upstream product

• 34123-66-5 O-isopropylisovanillin 
• 330667-10-2 1-{3-[(tert-butyldimethylsilyl)oxy]-4-methoxyphenyl}-ethanone 
• 330667-09-9 3-(tert-butyldimethylsilyloxy)-1-(1′-hydroxyethyl)-4-methoxybenzene 
• 97315-18-9 p-methoxy-m-(tert-butyldimethylsilyloxy)-benzaldehyde 
• 621-59-0 isovanillin 
• 330667-11-3 3′-(tert-butyldimethylsilyloxy)-4′-methoxy-2-bromoacetophenone 
• 439585-89-4 2,2,2-trifluoro-N-(2-iodo-5-methoxy-phenyl)-acetamide 
• 439585-86-1 4-ethynyl-2-isopropoxy-1-methoxybenzene 
• 215715-43-8 β,β-dibromo-3-isopropoxy-4-methoxystyrene 
• 25245-29-8 5-iodo-1,2,3-trimethoxybenzene 
• 439585-92-9 2-(3′-isopropoxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole 

Relevant academic research and scientific papers

A 2-phenyl-substituted-3-benzoyl-substituted indole preparation method

The invention relates to a preparing method of 2-(phenyl-substituted)-3-(benzoyl-substituted)indole, and particularly discloses a preparing method of 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3'',4'',5''-triethoxybenzoyl)-6-methoxyindole (OXi8006). The structure formula of the OXi8006 is shown in the specification. The OXi8006 can generate good antitumor activity (IC50=1.1 muM) by inhibiting tubulin polymerization and is an important clinical candidate for treating tumor. Synthesis of the OXi8006 by the method has characteristics of simple conditions, easy operation, short reaction steps and high total yield.

Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent

The natural products colchicine and combretastatin A-4 are potent inhibitors of tubulin assembly, and they have inspired the design and synthesis of a large number of small-molecule, potential anticancer agents. The indole-based molecular scaffold is prom

One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization

Benzo[b]furan and indole analogues of some recently identified benzo[b]thiophene inhibitors of tubulin polymerization have been prepared, and their biological activity has been assessed. Several very potent analogues were identified.